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Flashcards in Perinatal Mental Health Deck (35)
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1

Name at least 3 pregnancy-related disorders which tend to reoccur later in life

Pre-eclampsia (as hypertension), gestational diabetes, post-partum thyroid disease, postnatal depression, puerperal psychosis

2

Name at least 3 disorders which can be exacerbated by pregnancy

SLE, eating disorders, OCD, bipolar disorder

3

Name some sub-clinical syndromes unmasked by pregnancy

Thyroiditis, eating disorders, OCD

4

Define the 'baby blues' and state their prevalence (Henshaw, 2003)

Self-limiting depressive mood changes after delivery, prevalence 50%

5

State the peri and post-natal prevalence of minor depression

Perinatal: 11%
Postnatal: 13%

6

State the peri and post-natal prevalence of major depression

Perinatal: 3-5%
Postnatal: 4.7%

7

What percentage of post-partum women report obsessional thoughts of harm to their baby? (Wisner et al, 1999)

57%

8

State at least 5 risks of pharmacological intervention during pregnancy

Teratogenecity, obstetric complications, neonatal toxicity & withdrawal, neonatal complications, incompatibility with breastfeeding, neurodevelopmental disorders (autism), child psychopathology

9

State at least 5 risks of untreated mental illness during pregnancy

Increased risk of hospitalisation, worsening of long-term prognosis, suicide, premature delivery, low birth weight, still birth, early infant death, attachment disorders, slow infant cognitive development

10

Name 2 psychiatric disorders associated with premature delivery

Depression, schizophrenia

11

Name 2 psychiatric disorders associated with low birth weight

Anorexia nervosa, schizophrenia

12

Name a psychiatric disorder associated with still-birth and early infant death

Schizophrenia

13

Name a psychiatric disorder associated with slow infant cognitive development (Stein et al, 2014)

Depression

14

When in life is the relative risk of admission to hospital with a psychotic illness highest? (Kendell et al, 1987)

First 30 days after childbirth

15

What percentage of women who die 6 weeks to a year after pregnancy die from psychiatric causes?

23%

16

Describe the findings from the South London Child Development Study (SLDCS) on perinatal mental health and child development

Perinatal maternal depression increased the risk of child and adolescent psychopathology

17

Describe the findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) on perinatal mental health and child development

Antenatal maternal anxiety predicted behavioural and emotional problems in children, with a stronger impact on males

18

Describe the Barker hypothesis

Developmental programming in utero modifies the risk of disease later in life

19

What effects does the intrauterine environment have at an organ level?

It alters cellular and metabolic function, leading to altered appetite and lipogenesis

20

What effects does the intrauterine environment have at a cellular level?

It alters the number, size, and proliferation of cells, changing intracellular organisation

21

What effects does the intrauterine environment have at an epigenetic level?

It affects DNA methylation and modifies chromatin, leading to modified gene expression and signalling

22

Name the 4 neuorbiological correlates of perinatal mental health

Adrenaline-cortisol pathways, serotoninergic pathways, dopaminergic pathways, and oxytocin system

23

Which pathways are involved in depression?

Serotoninergic pathways

24

Which pathways are involved in anxiety?

Adrenaline-cortisol pathways

25

Which pathways are involved in psychosis?

Dopaminergic pathways

26

Which pathways are involved in addiction?

Dopaminergic system

27

How does the dopaminergic system ensure survival of the species

It counteracts the irritations of caring for children

28

Name at least 3 classes of psychotropic medication

Antipsychotics/ neuroleptics, selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs), mood stabilisers, anxiolytics/ sedatives

29

State the method of action of antipsychotics and name at least 2

Dopaminergic D2 antagonists - risperidone, olanzapine, quetiapine aripiprazole

30

State the method of action of SSRIs and name at least 2

Inhibit the reuptake of serotonin (5-hydroxytriptamine) in the synapse, increasing the bioavailable concentration and prolonging neuronal activity - fluoxetine, citalopram, escitalopram, sertraline