Pharm

Question 1

Gonorrhea/chlamydia Tx

Answer 1

ceftriaxone+azithromycin(or doxycyclin)

Question 2

clozapine

Answer 2

dopamine antagonist

Question 3

alprazolam

Answer 3

GABA agonist

Question 4

amitryptilene

Answer 4

norepinephrine/seratonin reuptake inhibitor

Question 5

sertraline

Answer 5

seratonin reuptake inhibitor

Question 6

phenelzine

Answer 6

MAO inhibitor

Question 7

decreases L-dopa effectiveness

Answer 7

vitamin B6

Question 8

estrogen effects on thyroid

Answer 8

decrease TBG(increase total T)

Question 9

vinblastine cell cycle affects

Answer 9

M phase

Question 10

acyclovir relies on

Answer 10

thymidine kinase phosphorylation

Question 11

cyclosporin MOA

Answer 11

inhibits calcineurin

Question 12

zero order(constant)elimination kinetics drugs

Answer 12

phenytoin, ethanol, salicylates

Question 13

cocaine during pregnancy

Answer 13

placental abruption&IU growth restriction

Question 14

beta lactams

Answer 14

penicillin, carbapenems, cephalosporins, cephamycins, monobactams(aztreonam)

Question 15

beta lactamase inhibitors

Answer 15

clavulonic acid, sul/tazobactam

Question 16

vancomycin MOA

Answer 16

prevents cross linking of d-ala(Gram+)

Question 17

daptomycin MOA

Answer 17

aggregates in membrane PTG, disrupts ion gradient(G+)

Question 18

aminoglycosides activity, MOA&examples

Answer 18

(G-aerobes) irreversably bind 30s, neo/strepto/gento/ tobramycin, amikacin

Question 19

tetracycline activity, MOA, resistance

Answer 19

binds tRNA at 30s ribosome(Ompf gene=resist)(cyclines)

Question 20

linezolid MOA, activity

Answer 20

binds 23s initiation complex of 50s ribsome(resistant G+)

Question 21

antimetabolite drugs(folic acid dihydropterate synthetase)

Answer 21

sulfonamide, trimethoprim, dapsone

Question 22

quinolone MOA/toxicity

Answer 22

inhibit topoisomerase II (gyrase) or IV, cartilage damage

Question 23

community acquired pneumonia 1st line

Answer 23

macrolides/doxycycline

Question 24

hospital acquired pneumonia/catheter UTI 1st line

Answer 24

fluoroquinolones (floxacins)

Question 25

rifampin MOA

Answer 25

inhibits RNA polymerase(G+cocci, meningitis prophylaxis), orange urine

Question 26

TB combo

Answer 26

rifampin, isoniazid, pyrazinamide, ethambutol

Question 27

doxycycline 1st line for

Answer 27

rickettsia, spirochetes, chlamydia, brucella (also a choice for anthrax, plauge, tularemia, legionella)

Question 28

macrolide/ketolide MOA

Answer 28

23s methylation of 50s subunit (romycins) inhibit peptidyltransferase

Question 29

often 2nd line(similar coverage) to penicillin(resistance)

Answer 29

macrolides

Question 30

common CDiff cause

Answer 30

clindamycin

Question 31

1st line staph aureus

Answer 31

penicillin(often oxacillin due to high resistance rate)

Question 32

syphillis 1st line

Answer 32

penicillin G

Question 33

gonnorhea/chlamydia 1st line

Answer 33

ceftriaxone+doxycycline OR azithromycin

Question 34

ethionamide/isoniazid MOA

Answer 34

inhibit mycolic acid synthesis

Question 35

ethambutol MOA

Answer 35

inhibit arabinogalactin synthesis

Question 36

amphotericin B MOA&activity

Answer 36

binds ergosterol& leaks(fungal, fluconazole/miconazole similar)

Question 37

albendazole MOA

Answer 37

binds colchicine preventing microtubule assembly

Question 38

HIV cocktail

Answer 38

2NRTI+1NNRTI or 2+1 protease inhibitor

Question 39

NRTI MOA

Answer 39

deoxynucleotide analogs w/ no 3' end, inhibit chain

Question 40

Na/K ATPase drug

Answer 40

digoxin/digitalis-cardiac glycosides-increase contractility

Question 41

chloramphenicol MOA/toxicity

Answer 41

bind 50s, gray baby syndrome, aplastic anemia(cheap)

Question 42

sulfonamide MOA/toxicity

Answer 42

inhibit dihydropterate synthase, kernicterus(kids), nephrotoxicity, hemolysis in G6PD deficiency

Question 43

flu Tx/MOA

Answer 43

zanamivir/oseltamivir-inhibit neuraminidase(decrease viral release)

Question 44

RSV/hep C Tx/MOA

Answer 44

ribavirin-inhibit guanine nucleotide synthesis(IMP dehydrogenase inhibitor)

Question 45

CMV 1st&2nd line Tx

Answer 45

ganciclovir(inhibits viral DNA polymerase), forscarnet(also 2nd line HSV)

Question 46

inhibit acetylaldehyde dehydrogenase(drunk quicker)

Answer 46

disulfirum-like(metronidazole, sulfonylureas)

Question 47

prolonged QT antibiotics

Answer 47

Macrolides(especially erythromycin)

Question 48

nephrotoxic antibiotics

Answer 48

aminoglycosides, vancomycin

Question 49

gout Tx

Answer 49

acute-NSAIDS/colchicine, prophylaxis-allopurinol/probenacid