Pharm extra

Question 1

hyperTG Tx, MOA, SE

Answer 1

fibrates, LPL upregulation, myositis(+gallstones&liver)

Question 2

low HDL Tx, MOA, SE

Answer 2

niacin, reduce VLDL secretion, flush/gout/acanthosis nigra

Question 3

high LDL Tx, MOA, SE

Answer 3

HMGCoA(inh to mevalonate), rhabdo(+liver)

Question 4

hypoglycemic toxicity DM drugs

Answer 4

2nd gen sulfonylureas(gli), insulins, amylin analog(lintide)

Question 5

lactic acidosis toxicity DM drug

Answer 5

metformin

Question 6

weight gain/HF toxicity DM drug/MOA

Answer 6

glitazones(PPARgamma-insulin sensitivity)

Question 7

disulfiram-like RXN DM drugs

Answer 7

1st gen sulfonylureas(amides)

Question 8

longish acting insulins

Answer 8

glargine, detemir, NPH

Question 9

TNF-alpha inhibitors

Answer 9

infliximab, adalimumab, etanercept

Question 10

HIT coag 2nd line

Answer 10

rudins-inhibit thrombin

Question 11

ACS/stenting 2 options

Answer 11

ADP-R(grels/ticlodipine), GPIIb/3A Inh(abcmab/fIIbs)

Question 12

claudication drugs

Answer 12

cilostozol, dipyridamole(phospho III inhibitors)

Question 13

MTX vs 5FU toxicity

Answer 13

leucovorin vs thymidine rescue

Question 14

cyclophosphamide MOA, SE+Tx

Answer 14

link guanine N-7, hemorrhagic cystitis-prevent w/mesna

Question 15

pulmonary HTN Tx, MOA

Answer 15

bosenten-endothelin1 inhibit

Question 16

reduce uterine contractions, MOA

Answer 16

terbutaline-beta2-agonist

Question 17

clomiphene use&MOA

Answer 17

infertility/PCOS, partial agonist SERM

Question 18

emergent glaucoma Tx

Answer 18

pilocarpine-increase outflow contracting ciliary muscle

Question 19

random opiods

Answer 19

meperidene, diphenoxylate, dextromethorphan, butorphanol

Question 20

stevens-johnson drugs

Answer 20

carbamazepine, ethosuxamide, phenytoin, lamotrigine

Question 21

barbiturates(include thiopental) vs benzos MOA

Answer 21

increase duration of Cl- channel opening vs increasing frequency= increase in GABA in both

Question 22

NMDA block anesthesia

Answer 22

ketamine(PCP analog)

Question 23

succinylcholine MOA, OD Tx, similar agents

Answer 23

sustained NM depolarization, ACh-esterase inh(neostigmine) but only in phase 2. curiums

Question 24

dantrolene use

Answer 24

malignant hyperthermia+neuroleptic malignant syndrome

Question 25

benztropine, selegine/capones, amantadine, ldopa, bromocriptine/pramiprexole/ropinarole use+MOA

Answer 25

parkinsons-antiM(tremor), MAOB inh(less dopa degraded), inc dopa release, dopa, dopa agonists

Question 26

reserpine/tetrabenzine, haloperidol use+MOA

Answer 26

huntingtons-inhibit VMAT(limit dopa release), dopaR ant

Question 27

sumatriptan contraindication

Answer 27

CAD/prinzmetal(causes vasospasm)

Question 28

memantine, donepezil/galantamine/rivastigmine use+MOA

Answer 28

alzheimers-NMDA antagonist, ACh esterase inhibitors

Question 29

alcohol withdrawal Tx

Answer 29

benzos(pams/lams/chlordiazepoxide)

Question 30

trifluoperazine, fluphenazine, haloperidol MOA&SE(TFH)

Answer 30

D2 block high potency-EPS(kinesias)H=NMS+tardive

Question 31

thioridazine, chlorpromazine SE

Answer 31

low potency-alpha/H/cholinergic SE, reTinal, Corneal

Question 32

weight gain drugs+other SE

Answer 32

clozapine/olanzapine-atypicals, c=agranulocyte+seizure

Question 33

long QT drug+other atypicals

Answer 33

ziprasidone(quietapine, risperadone, aripiprazole)

Question 34

heart block drug, other SE

Answer 34

lithium-tremor, hypothyroid, polyuria, ebsteins in kids

Question 35

anxiety med for alcoholics, MOA

Answer 35

buspirone-5HT1A

Question 36

iptyline/ipramine, doxepin, amoxepine SE+Tx

Answer 36

3Cs(cardio/convulsion/coma), NaHCO3

Question 37

seratonin sydrome causes, Tx

Answer 37

SSRI, SNRI, TCA, MAO, cyproheptadine

Question 38

venlafaxine, duloxetine MOA+SE

Answer 38

SNRI-high BP+stimulant effects

Question 39

MAO inhibitors+SE

Answer 39

MAO Takes Pride In Shanghai-Tranylcypromine, phenelzine, isocarboxazid, selegine, HTN crises

Question 40

mirtazapine, maprotiline, trazodone MOAs/SE

Answer 40

a2+5HT2/3 antagonist-weight gain/sedation, NERI-hypotension, serotonin reuptake-PRIAPISM