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Repro Flashcards

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1
Q

teratogenic period

A

weeks 3-8

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2
Q

conyloma association

A

HPV 6&11

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3
Q

koilocytic change

A

HPV

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4
Q

HPV 16, 18 lesions

A

dysplasia-intraepithelial neoplasia, progress to carcinoma

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5
Q

thin white vulvar skin vs thick white

A

lichen sclerosis, lichen simplex chronicus (rule out carcinoma)

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6
Q

paget’s disease vs. melanoma labs

A

paget=PAS+ keratin+ S100-, melanoma opposite

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7
Q

female reproductive tract derivation

A

mullarian duct(paramesonephric)

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8
Q

vaginal adenosis association

A

DES in pregnancy(persistent columnar epithelium) then possible clear cell adenoma

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9
Q

grape-like mass

A

rhabdomyosarcoma(desmin&myogenin+)

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10
Q

vaginal cancer spread

A

lower 1/3=inguinal, upper 2/3=iliac

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11
Q

HPV virus type& high risk protein targets

A

DNA, e6=p53, e7=Rb

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12
Q

complication of cervical cancer

A

bladder invasion

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13
Q

asherman syndrome lesion

A

post procedural uterine adhesions(loss of basalis)

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14
Q

endometrial polyp cause

A

tamoxifen

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15
Q

unopposed estrogen causes

A

endometrial hyperplasia(possibly endometroid carcinoma)

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16
Q

sporadic endometrial cancer lesion

A

p53, serous papillae on atrophic endometrium

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17
Q

psammoma body causes

A

papillary cancer thyroid, papillary sporadic endometrial, meningioma, mesothelioma

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18
Q

leiomyoma vs leiomyosarcoma

A

multiple white whorled vs. one hemorrhaging

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19
Q

endometriosis common lesions

A

ovary chocolate cysts, uterus/pouch of douglas/fallopian, soft tissue gunpowder lesions

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20
Q

theca cell function

A

LH causes androgen production

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21
Q

granulosa cell function

A

FSH converts androgen to estrogen(egg maturation)

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22
Q

corpus luteum function

A

secrete progesterone

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23
Q

polycystic ovarian syndrome

A

increased LH(LH:FSH>2) associated to T2DM(fat)

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24
Q

BRCA1 reproductive tumors

A

serous carcinoma of ovary/fallopian tubes

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25
brenner tumor characteristic
urothelium cells
26
most common germ cell tumor in females
cystic teratoma
27
most common malignant germ cell tumor
dysgerminoma(looks like egg, high LDH)
28
endodermal sinus tumor pathology
schiller-duvall bodies, high AFP, mimics yolk sac(most common in kids)
29
choriocarcinoma lab
high bHCG(small and hemorrhagic fast spread)
30
granulosa-theca cell tumor lab
excess estrogen
31
reinke crystals(pink) tumor type
leydig
32
fibroma association
pleural effusion, ascites(Meigs syndrome)
33
bilateral krukenberg tumor association
mucinous tumor(especially gastric carcinoma)
34
pseudomyxoma peritonii lesions
primary appendix tumor+mucinous ovarian
35
ectopic pregnancy risk factors
PID, endometriosis(scarring)
36
preeclampsia triad
HTN, proteinuria, edema(seizures=ecclampsia-deliver)
37
HELLP
hemolysis elevated liver enzymes low platelets(liver microangiopathy is cause)
38
passing grapelike masses
hydatidaform mole (snowstorm US)
39
partial mole features
69(two sperm+mom)+fetal tissue
40
complete mole features
46(just two sperm) all villi edematous, high risk
41
hypospadias embryology
failure of urethral folds to close
42
epispadias embryology/association
abnormal genital tubercle positioning, bladder exstrophy
43
lymphogranuloma venerum bug&pathology
Chlamydia L1-3(obligate intra), necrotizing lymph nodes
44
cryptorchidism association
sterility, seminomas
45
orchitis/prostatitis bugs
chlamydia/gonorrhea, ecoli/pseudamonas adults, mumps
46
hyrdocele fluid location
tunica vaginalis(improper closure of processus vaginalis)
47
seminoma pathology
large clear cells(good prognosis) Tx-radiotherapy
48
embyonal pathology
necrotic/hemorrhagic primitive cells(chemo-sometimes differentiates) high AFP/bHCG sometimes
49
most common kids tumor+labs
yolk sac, high AFP, schiller duval(glomerulus like)
50
choriocarcinoma lab/side effects
high bHCG-gynecomastia/hyperthyroid
51
teratoma male vs female
benign in F, malignant in M
52
most common testicular mass cause in old men
diffuse large Bcell lymphoma
53
BPH Tx
a1 antagonist/5a reductase
54
most common cancer in men
prostatic adenocarcinoma(posterior periphery) PSA>10
55
cancer NOT to biopsy in men
testicular-most malignant
56
prostate cancer spread
lumbar-osteoblastic metastastes(Tx-androgen inh/GnRH analog)
57
periductal mastitis association
smoking(vit A deficiency), nipple retraction
58
green-brown nipple discharge
mammary duct ectasia
59
normal breast change
fibrocystic-blue dome cysts(apocrine metaplasia NO cancer risk)
60
bloody nipple discharge
intraductal papilloma papillary carcinoma(no myoepithelial)
61
most common mass
fibroadenoma-change with estrogen
62
comedo ductal CIS
central necrosis/calcification(pagets if reaches nipple)
63
BRCA1 lesion
medullary carcinoma
64
lobular carcinoma in situ pathology
lacking E cadherin(risk factor, Tx-tamoxifen)
65
Tx-response for breast cancer based on
Estrogen/progesterone(tamoxifen), Her2Neu(trastuzamab) receptors
66
male breast cancer
BRCA2/klinefelters(ductal carcinoma)
67
gynecomastia causes
spirinolactone, digitalis, cimetadine, alcohol, ketaconazole
68
GnRH analog drug
leuprolide
69
BPH Tx&MOA
finasteride-5-alpha reductase inhibitor or tamsulosin-a1ant
70
ketoconazole use&MOA
PCOS hirsuitism-inhibit 17,20 desmolase(steroid synthesis)
71
abortificants
mifepristone&misoprostol(PGE1)

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