Test 2: 8 cancer Flashcards by jillian Bastidas

— is common in cats and huskys and akitas

Eosinophilic Granulomas

Non-Neoplastic, Proliferative & Inflammatory Lesions

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Eosinophilic Granulomas look like

Ulcerated Solitary Masses & Plaques

found in the mouth

Eosinophilic granulomatous inflammation with
flame figures

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Eosinophilic Granulomas

flame figures
inflammatory lesion in cats and arctic dog breeds

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Chronic Lymphocytic Plasmacytic-
Gingivitis-Stomatitis (LPGS) Complex occurs in

cats

88% have feline herpes or feline calicivirus

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what does Chronic Lymphocytic Plasmacytic-
Gingivitis-Stomatitis (LPGS) Complex look like

Gingiva & buccal mucosa (Caudal pharynx, tonsil region!)
* Raised, thickened, hyperemic plaques → erosion and ulcers

associated with Feline Odontoclastic Resorptive Lesions (FORL)

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LPGS is associated with

Feline Odontoclastic Resorptive Lesions (FORL)

most cases also have feline herpes and feline calici

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LPGS cause severe submucosal —-

lymphoplasmacytic
infiltrates that lead to erosion and ulcers

may be hypersensitivity rxn or immune mediated

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cat

Chronic Lymphocytic Plasmacytic-
Gingivitis-Stomatitis (LPGS)

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Papular Stomatitis

ORF in camelids

caused by parapoxviruses

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Papular Stomatitis is caused by

Parapoxviruses- Zoonontic

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pathogenesis of papular stomatitis (ORF)

Epithelial cell infection → Virus-induced hyperplasia &
dysplasia → Epithelial degeneration → Inflammation- expands
submucosa / dermis too! → Pustules, ulcers & crusts

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bovine viral papular stomatitis

caused by parapoxvirus

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— can spontaneously regress

papillomas

stimulate cytotoxic T cell response

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papilloma lesion has —stratified squamous
epithelium (+/- viral inclusions)

Hyperplastic & dysplastic

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papillomas are caused by

virus
congenital
idiopathic

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papillomas look

big, cauliflower masses on the mouth or lips

multiple or solitary

Exophytic, verrucous

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papillomas are benign or metastatic

benign neoplasms

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Fibrogingival Hyperplasia (FGH)

benign- found in older boxers

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papillomas are common in — animals

younger

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— benign neoplasm is Associated with chronic
gingivitis/periodontal dz!

Fibrogingival Hyperplasia (FGH)

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differential for Fibrogingival Hyperplasia (FGH)

Peripheral
Odontogenic Fibroma (POF)

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Fibrogingival Hyperplasia (FGH) looks

firm smooth nodules

older dogs

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FGH cause — histo

Hyperplastic mucosa Hyperplastic

Proliferative fibrovascular
Mucosa tissue

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Peripheral Odontogenic Fibroma (POF) is a neoplasm of

the periodontal ligament

older dogs

previously called epulis/epulides

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Peripheral Odontogenic Fibroma (POF) are metastatic or benign

benign neoplasm of the periodontal ligament

what do Peripheral Odontogenic Fibroma (POF) look like

benign proliferative mass near teeth large and firm pedunculated or sessile looks similar to FGH or acanthomatous ameloblastoma

histo of Peripheral Odontogenic Fibroma (POFs)

Peripheral Odontogenic Fibroma Periodontal ligament-like stroma

Acanthomatous Ameloblastoma (AA) has ---, but post surgical recurrence is common

no metastasis aggressive neoplasm infiltrates bone- difficult to get good margin

Acanthomatous Ameloblastoma (AA) grossly resembles

benign fibrogingival hyperplasia or POF

histro of Acanthomatous Ameloblastoma (AA)

neoplasm driven by odontogenic epithelium (ameloblasts) →opposite of POFs cords and solid sheets of neoplastic ameloblasts(cells which secrete the enamel proteins) +/- osseous & dentinous elements

Acanthomatous Ameloblastoma (AA) could be POF- need histo to determine

Oral Melanoma are benign or malignant?

malignant- very poor prognosis rapid metastasis to anywhere- spread in lymphatics

--- is most common canine oral malignancy

oral melanoma 40% of tumors in mouth less common in cats anywhere is mouth, tissue destruction, rapid metastasis to anywhere in the body

Malignant Melanoma

oral squamous cell carcinoma is found most commonly in

cats and dogs>> horses and cattle older animals

oral squamous Cell Carcinoma in cats is found ---

Sublingual mucosa > gingiva

oral squamous Cell Carcinoma in dogs is found ---

unilateral tonsil and gingiva

oral squamous Cell Carcinoma in horse and cattle is found in ---

tongue and oropharynx

oral squamous Cell Carcinoma is benign or malignant

malignant poor prognosis locally invasive and aggressive metastasis to regional lymph nodes

malignant cat neoplasm

oral squamous Cell Carcinoma

oral squamous Cell Carcinoma looks

large ulcerated masses extensive surface necrosis & ulceration highly infiltrative and destroy local tissue and bone Firm masses from desmoplasia

desmoplasia

Causing or forming adhesions or fibrous connective tissue within a tumor.

histo of oral squamous cell carcinoma

Exophytic or endophytic Cords & nests of atypical squamous epithelium → desmosomes, keratinization→ “keratin pearls” High mitotic index 2˚ Ulcers, inflammation Desmoplasia→ firm!

--- can be Solid tumors (masses) & diffuse infiltrative forms in the GI

Alimentary Lymphoma Lymphosarcoma

cat Alimentary Lymphoma/Lymphosarcoma cause ---

Vomiting, diarrhea, or constipation infiltrative disease causes exudative diarrhea

prognosis of cat with Lymphosarcoma

Poor prognosis (75% 2mo mortality w/o treatment)

cat with Lymphosarcoma is caused by --- or ---

FeLV sponatneous can be seen in all ages of cats affects the Jejunum, ileum +/- liver & kidney

--- is the most common GI neoplasm in cows

abomasal LSA (lymphocarcoma)

cat intestine presents with Vomiting, diarrhea, or constipation

solid form Alimentary Lymphoma/Lymphosarcoma

cat

diffuse form of Alimentary Lymphoma/Lymphosarcoma looks like johne's disease in cow

Most common GI neoplasia in the dog (seen in all species); 2nd most common GI neoplasia in the cat

Adenocarcinoma

cat

Alimentary Lymphoma/Lymphosarcoma (LSA)

adenocarcinoma cause --- neoplasms with --- that form white --- lesions with stenosis --- lesions

invasive desmoplasia firm napkin-ring

adenocarcinoma will ---

metastasis carcinomatosis

clinical signs of adenocarcinoma in the stomach

gastric ulcer, vomiting, anorexia

clinical signs of adenocarcinoma in the colon

constipation pain & straining on defecation (tenesmus), blood in feces (hematochezia)

prognosis of adenocarcinomas

poor- local invasion and metastasis very common in Dogs

dog

Intestinal adenocarcinoma with desmoplasia → Stenosis (“NAPKIN RING” lesion)

carcinomatosis

--- Associated with gastric (pyloric) & proximal duodenal ulcers. Due to increased circulating histamine produced by tumor

mast cell tumors

--- is a combo of hypersensitivity and immune mediated disease and will have what cell types

Inflammatory Bowel Disease will have Eosinophilic +/or lymphoplasmacytic inflammation

IBD will infiltrate the --- and --- and cause erosion and ulcers leading to ---

lamina propria submucosa crypt atrophy and fibrosis

chronic inflammation will cause dysmotility and cause smooth muscle

hypertrophy

some things that cause hypersensitivity reaction of IBD are

Environmental or food allergy Dysbiosis Parasites +/- “Pre-lymphoma” (esp lymphoplasmacytic form

prognosis of IBD

Chronic, progressive, can respond to immunomodulation Cause of chronic colic- sm mm hypertrophy→ obstruction

feline

FE Eosinophilic Enteritis → Smooth Muscle Hypertrophy caused by IBD

(+/- viral etiology, benign, proliferative in mouth of young animals

papilloma

Adenocarcinoma (---)- invasive→ 2° gastric ulcers & metastasis

dogs

Squamous cell carcinoma (---) invasive +/- metastasis

horses

Lymphoma (BV, FE): ---cause in cattle (BLV) & cats (---)

lentiviral FeLV

IBD (FE, K9, EQ)→ progressive→ dysmotility & smooth ---

muscle hypertrophy

Lymphoma (FE, K9, EQ, PO)→ --- forms→ metastatic

nodular & diffuse

Mast cell tumor (K9, FE)- invasive, metastatic→ 2° ---

gastric ulcers

---: (benign proliferative) ZOONOTIC!!!

Papular stomatitis & ORF

Test 2: 8 cancer Flashcards

(74 cards)