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Fall 22: micro > Test 2: DNA viruses > Flashcards

Test 2: DNA viruses Flashcards

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1
Q

class I viruses are

A

ds DNA virus

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2
Q

class II viruses are

A

ss(single stranded) DNA viruses

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3
Q
A

circoviridae
parvoviridae

class II ss DNA virus

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4
Q
A

papovaviridae

class I ds DNA

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5
Q
A

adenoviridae

class I ds DNA
has its own DNA polymerase

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6
Q
A

herpesviridae

class I ds DNA

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7
Q
A

poxviridae

class I ds DNA

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8
Q
A

asfarviridae

class I ds DNA

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9
Q

— serotype is the pathogenic circovidisae

A

PCV2

found in pigs

PCV1 is not pathogenic

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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10
Q

what do circoviridae look like

A

smallest 20-24 nm
non enveloped
icosahedral
ss circular DNA

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11
Q

how do circoviridae replicate

A

Replicates DNA in the nucleus of the infected cell and assembles capsid in the nucleus

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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12
Q

what genes make up circoviridae

A

two genes, 3 gene products
Rep and Rep’ (Rep’ is spliced form of Rep) needed for genome replication

Cap protein forms the capsid (single structural protein)

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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13
Q

— needed for
genome replication for circoviridae

A

Rep and Rep’

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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14
Q

— protein forms the capsid of cicoviridae

A

Cap protein

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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15
Q

— relies heavily on host (since only 3 gene products) Needs host cells to be rapidly dividing (S phase)

A

Circoviridae

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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16
Q

porcine circovirus cause

A

Post-weaning Multisystemic Wasting Syndrome (PMWS)

Porcine Circovirus Associated Diseases (PCVAD)

caused by PCV2 serotype

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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17
Q

symptoms of Circovirus in pigs

A

wasting, resp. distress, enlargement of lymph nodes, diarrhea, paleness of skin, generalized lymphocyte depletion. rash

Post-weaning Multisystemic Wasting Syndrome (PMWS)

Porcine Circovirus Associated Diseases (PCVAD)

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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18
Q

how to transmit PMWS

A

direct contact, with coinfection

Post-weaning Multisystemic Wasting Syndrome
porcine circovirus- PCV2

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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19
Q

regularly found in a population or area

A

endemic

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20
Q

widespread occurrence in a population or area at a particular time

A

epidemic

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21
Q

widespread replication affecting numerous individuals in numerous countries.

A

pandemic

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22
Q
A

Post-weaning Multisystemic Wasting Syndrome (PMWS) caused by porcine circovirus (PCV2)

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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23
Q

treatment for PCV2

A

vaccines

porcine circovirus

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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24
Q

human circoviruses

A

TT-Virus and TT-like Mini Virus (TLMV): >70% population, asymptomatic.

circoviridae- smallest, non enveloped, icosahedral, ss circular DNA

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25
3 groups of parvoviridae
Erythroviruses Dependoviruses (adeno-associated virus or AAV) Autonomous Parvoviruses (no helper needed) ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA
26
--- causes slapped cheek syndrome
erythrovirus type of parvoviridae human parvovirus B19 ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
27
dependoviruses are a subgroup of ---
parvoviridae adeno-associated virus (AAV) | need helper virus to survive ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
28
--- is a receptor for feline and canine parvoviruses
Transferrin receptor (TfR) ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
29
what are the three capsid proteins for autonomous parvovirus
VP1 VP2- attachment protein VP ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
30
are parvo viruses easy to get rid of?
no envelope= resistant to detergent very stable in environment for 6-12 months Inactivated by formalin, sodium hypochlorite (bleach) ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
31
platonic solid with 20 faces made of equilateral triangles. Icosahedra have 2-fold, 3-fold and 5-fold axes
icosahedron ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
32
where does replication of parvovirus occur
inside the nucleus of host cell ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
33
parvovirus use --- to replicate
host DNA polymerase ## Footnote negative sense DNA→use host DNA polymerase to make + sense dsDNA template. Use host RNA polymerase to make mRNA → proteins proteins move back into nucleus to form viron
34
basic steps of parvovirus replication
* use host DNA polymerase to form + sense DNA * use host RNA polymerase for mRNA * proteins are formed in the cytoplasm and then move back into the nucleus * proteins assemble into capsid with viral DNA inside * virus released by cell lysis ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
35
Feline Parvovirus is also called
feline panleukopenia virus and feline distemper virus | Distinct from canine distemper (an RNA virus similar to measles) ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
36
prognosis for FPV
Prognosis is very poor (overall 33-50% survival rate), especially for very young kittens | Feline parvovirus ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
37
Feline parovirus symptoms
loss of appetite, fever, lethargy, vomiting,diarrhea **leukopenia** | respiratory and GI ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
38
where does FPV replicate in the host
pharyngeal lymphoid tissue then spreads to blood (leukopenia- will white blood cells) and other tissues will spread to epithelial cells lining small intestine →diarrhea | Feline Parvovirus ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
39
how to spread FPV
spread by direct contact with infected cats, infected bedding, food dishes. can be shed 6 months after infection | no envelope = very stable in environment ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
40
what does vaccine break mean
presence of maternal antibody can prevent vaccine “take” | Feline parvovirus vaccine is time sensitive
41
---- was the previous parvovirus of canines – caused only mild disease in older animals - also called MVC (minute virus of canines)
CPV-1 | canine parvovirus ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
42
where did CPV-2 come from
mutation in FPV (feline parvo virus) CPV-2 did not infect cats mutated again to 2a, 2b and 2c→2a and 2b can infect cats ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
43
Two mutations in --- allowed FPV to use canine version of the Transferrin receptor (TfR) and infect canine cells. Became known as ---
VP2 (capsid protein) CPV2 (canine parvovirus) ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
44
CPV 2 caues ---- in 4-8 weeks old dogs
Myocarditis in pups of 4-8 weeks of age Sudden death without preceding clinical signs. Extensive damage to myocardium. ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
45
CPV 2 caues ---- in 8-12 weeks old dogs
leukopenia/enteritis Vomiting can be severe ; bloody diarrhea ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
46
vaccination schedule for CPV
vaccinate at 2-3 week intervals, starting at 6-8 weeks to 16-20 weeks. | need to avoid maternal antibodies
47
PPV cause
SMEDI - Still birth, Mummification, Embryonic Death and Infertility | porcine parvovirus ## Footnote Parvoviridae-small, non enveloped, icosahedral, ss circular DNA (classII)
48
papovaviridae are ---
small, non enveloped, icosahedral, ds circular DNA (class I) | includes papilloma, polyoma, simian vaculating virus (SV40)
49
papovaviridae replicate genome in the --- and capsids assemble in ---
nucleus nucleus ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA (class I)
50
how many genes does papillomavirus make
9 **2 capsid(late):** 1 major (L1) and 1 minor (L2) **7 early proteins:** E6 and E7 used for cell trasformation ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA (class I)
51
the early genes in papillomavirus are for
DNA replication E6 and E7 involved in cell transformation | early = before DNA replication ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
52
late papillomavirus proteins are used for
make structual components L1( major) and L2( minor)→make capsid | late - made after DNA replication
53
early or late proteins are used for DNA replication
early
54
early or late proteins are used for strucural components
late
55
---- expressed alone can assemble into virus like particles (VLP’s)
L1 | late protein made by the papillomavirus ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
56
Papillomavirus capsids assemble together even in the absence of genome. Formation of ----
Virus-like particles (VLP) ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
57
how do papillomavirus vaccines work?
papillomavirus L1 protein can form capsid without viral DNA empty virus capsid will cause body to form antibody and protect host from HPV (human papilloma virus) ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
58
HPV vaccine recommended for children age ---
11-12 | vaccine made from empty capsid ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
59
HPV cause
cervical cancer oral cancer | human papilloma virus vaccine uses L1 protein ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
60
what cells do papillomavirus attack
basal layer epidermal cell | will multiply as skin cells differentiates and keratinozed ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
61
papillomavirus DNA is maintained as a --- in the host nucleus
episome | live in epidermal skill cells ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
62
how does papillomavirus cause cancer
circular viral DNA gets accidently added to the host linear DNA E6 and E7 on the viral DNA inhibit tumor suppression →over growth of cells no longer make virus, makes cancer instead ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
63
Overexpression of E6 and E7 lead to ___
cell proliferation, cancer | papilloma virus genome gets added to host DNA and cause cancer ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
64
papilloma virus in animals cause
warts | unlikely to cause cancer, like in humans ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
65
Bovine papilloma type 1,3,5 cause
fibropapillomas on head, neck, teats ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
66
type 4 bovine papilloma virus cause
Papillomas of digestive tract often seen only postmortem. Sometimes lead to carcinomas ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
67
Equine papillomavirus is spread by
contact with other horses (young) | warts- that resolve on their own ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
68
Equine sarcoid is spread by
caused by Bovine papillomavirus type 1 and 2 contact- can spread cow to horse, and horse to horse ~ 70% occur in horses < 4 yrs old do not regress ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
69
Equine sarcoid is caused by
Bovine papillomavirus type 1 and 2 | <4 year old horses, spread cow to horse, horse to horse, do not regress ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
70
how to treat equine sarcoid
surgery and immunotherapy caused by Bovine papillomavirus type 1 and 2, do not regress | <4 year old horses, spread cow to horse, then horse to horse ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
71
Feline PV causes ---
Multiple, crusted, plaques | will regress ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
72
Canine PV cause
warts on oral mucosa, eyelids, **mouth** and muzzle of dogs spread by direct and indirect contact will regress ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
73
polyomaviruses capsids are made by
VP1, VP2, VP3 | VP1- attaches to host cell receptor ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
74
SV40
simian vaculoating virus large T antigen cause tumor by supressing p53 and RB ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
75
mouse polyomavirus cause ---
subclinical infection in mice ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
76
Avian polyoma virus also called
Budgerigar Fledgling disease
77
Avian polyoma virus cause
copious shedding in young birds can lead to systemic infection | Budgerigar Fledgling disease ## Footnote papovaviridae- papilloma and polyoma - small, non enveloped, icosahedral, ds circular DNA virus (class I)
78
adenoviruses have ---- project from vertices of icosahedral capsid
Fibers (spikes) attachment to cell surface receptors ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
79
adenovirus cause --- in humans
cold like symptoms pink eye severe respiratory disease in young or immune compromised people ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
80
Adenovirus can cause --- in people with reduced immune functions and/or pre-existing respiratory or cardiac conditions.
severe respiratory disease ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase (CAV-1(blue eye), CAV-2)
81
--- are used for gene therapy
adenovirus | will package up modified DNA and carry it ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
82
how does johnson and johnson vaccine work
adenovirus that was changed ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
83
adenoviruses uses host RNA polymerase, but---- DNA polymerase
makes its own ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
84
Adenovirus makes two early genes --- that stimulate cell into S phase to help with DNA replication
E1A and E1B ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
85
E1A and E1B are oncogenes for --- virus
adenovirus will inactivate p53 and Rb leading to uncontrolled cell growth ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
86
polyomarvirus makes --- adenovirus makes --- papillomarvirus make --- that inhibits RB
large T E1A E7 ## Footnote non enveloped, icosahedral, ds DNA virus (class I)
87
polyomarvirus makes --- adenovirus makes --- papillomarvirus make --- that inhibits p53
Large T E1B E6 | p53 stops and tries to fix cell ## Footnote all these are non enveloped, icosahedral, ds DNA virus (class I)
88
--- cause infectious canine hepatitis, severe generalized disease
Canine adenovirus type 1 hepatitis blue eyes young dogs susceptible | spread oral fecal ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
89
hepatitis blue eyes is caused by
canine adenovirus type 1 | oral fecal route puppies target liver ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
90
animals that recover from CAV-1 with have---
lifelong immunity | canine adenovirus - infectious hepatitis, blue eyes, generalized disease ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
91
canine adenovirus type 1 targets the liver and virus persists in kidney, so ----spreads virus
urine, feces and saliva young dogs | blue eye hepatitis ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
92
----- cause liver swelling, cell damage, hemorrhages and often death due to shock
canine adenovirus type 1 | blue eye hepatitis yound dogs spread fecal, urine, saliva ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
93
egg drop is caused by
adenovirus ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
94
CAV-2 is spread by ---
aerosal transmission | Canine adenovirus- cause respiratory disease- kennel cough ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
95
egg drop syndrome is caused by
adenovirus | inflammatory lesions in oviduct ## Footnote adenovirus - small (70-90nm), non enveloped, icosahedral, spikes, ds linear DNA virus 36Kb (class I), has its own DNA polymerase
96
herpesviruses are --- shaped
enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
97
---- are a hallmark of Herpesviridae
Latent infections ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
98
alphaherpesvirus such as --- will grow ---
**HSV-1** - cold sore- trigeminal ganglia in the head **HSV-2 **sexually transmitted **VZV**- chicken pox- ganglia throughout the body in neural tissue ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
99
cytomegaloviruses are ---
betaherpes grow slowly latency in salivary glands, kidney and lymphocytes | CMV ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
100
--- type of herpes has latency in sensory neurons
alpha HSV-1 cold sore, VZV- chicken pox ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
101
---- type of herpes has latency in salivary glands, kidneys and lymphocytes
beta CMV (cytomegalovirus) grows slowly ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
102
what type of herpes has lactency in the lymphoid cells
gamma EBV- mono ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
103
egress system of herpes virus
exocytosis- complex process that does not kill host cell ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
104
herpes replication cycle
envelope fuses with plasma membrane staggered gene expression: early DNA replication, late structural proteins assembly of capsid in the nucleus of host cell exocytosis without killing the host cell ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
105
--- is a lifelong phase of the herpes infection
Latency | stress with reactivate virus ## Footnote Upon entering the neuron of sensory ganglia (non dividing cell), the virus does not initiate replication (lytic cycle) replicate but goes latent with no or very few genes being expressed and not virus produced
106
EEHV effect
elephants | killer virus ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
107
Equine herpesvirus 1 cause
respiratory disease abortions neurologic symptoms →Equine Herpes Myeloencephalopathy (EHM) (abnormal gait, hind limb paralysis) ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
108
vaccines for herpes will
reduce severity of disease but not prevent infection ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
109
Equine herpes Myeloencephalopathy is caused by
Equine herpes virus 1 cause abnormal gait, hind limb paralysis EHV1 also causes URI and abortion ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
110
bovine herpes virus 1 is also called ----
infectious bovine rhinotracheitis | cause respiratory disease, conjunctivitis, abortions ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
111
BHV1 is spread by
droplet, genitals | cause respiratory disease, conjunctivities, abortion in cows ## Footnote also called infectious bovine rhinotracheitis and infectious pustular vulvovaginitis
112
--- Virus latent in trigeminal or sciatic ganglia.
bovine herpes virus 1 Infectious bovine rhinotracheitis (IBR) infectious pustular vulvovaginitis (IPV) cause respiratory disease, conjunctivitis, abortions ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
113
Aujeszky's disease is caused by ---
pseudorabies virus (type of herpes virus) spread from pigs to cats, dogs and cows severe in young animals (100% death) moderate in animals 6-8 months ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
114
--- type of herpes is severe in young animals, 100% death. Less severe in animals >6-8 months
pseudorabies virus Aujeszky's disease | herpes that infect pigs and can be transmitted to cows, dogs and cats ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
115
symptoms of pseudorabies virus
Acute resp. disease, encephalitis * Neurologic signs resemble rabies * Pregnant animals may abort spread by saliva and nasal secretions primary host pig →dog, cat, cow | Aujeszky's disease - herpes virus ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
116
Canine herpesvirus 1 is spread by
direct contact -virus shed from infected older animals that harbor latent virus; or in neonates during birth ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
117
--- is the leading cause of death in puppies
canine herpes virus 1 ## Footnote Death most common in neonates or in first 2-3 weeks after birth; Acute disease. Begins in pharynx and tonsils, viremia, spread to all organs including CNS, kidneys, etc. Incubation: about 1 week to symptoms.
118
Feline herpesvirus cause
respiratory infection eye infection→ can cause blindness | latency in trigeminal ganglion ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
119
Feline herpes virus has latency ---
in the trigeminal ganglion leads to eye issues - blindness ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
120
feline herpes virus is passed by ---
direct contact 80% of cats are carriers | cause URI and eye issues ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
121
ILTV cause
respiratory infection in chickens of all ages | Avian Infectious Laryngotracheitis (Gallid herpes virus 1) ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
122
Marek’s Disease Virus (MDV)
alphaherpesvirus even though it causes tumors Lymphoproliferative disease of chickens older birds get neuro symptoms and generalized symptoms such as diarrhea | spread by free virus in dander ## Footnote herpes- complex, enveloped, ds DNA virus (class I), linear in virion, circular in host, icosahedral capsid
123
Lymphoproliferative disease of chickens is caused by
Marek’s Disease Virus (MDV) it is an alphaherpesvirus even though it causes tumors | neuro and generalized symptoms vaccinate eggs
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what disease do we vaccinate eggs for
**Marek’s Disease Virus (MDV)** it is an alphaherpesvirus even though it causes tumors (Lymphoproliferative disease of chickens)
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--- effect gills of koi fish
Koi herpesvirus alpha herpes | Gill necrosis, superficial hemorrhage, enlargement of kidney and liver
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poxviruses are ----
large complex, enveloped, ds DNA virus (class I), brick shaped, stable in environment
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--- virus are stable in the environment even though they are enveloped
poxviruses ## Footnote poxvirus- large complex, enveloped, ds DNA virus (class I), brick shaped, stable in environment
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two human host poxviruses
smallpox molluscum contagiosum ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement
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where does poxvirus replicate
in the cytoplasm | different from other DNA viruses have their own DNA and RNA polymerase ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement, have their own DNA and RNA polymerase
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---- have their own DNA polymerase and RNA polymerase and can replicate in the host cytoplasm
poxvirus ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement, have their own DNA and RNA polymerase
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Poxvirus have ---- gene products also include proteins for immune evasion: Lots of immune evasion genes
Early ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement, have their own DNA and RNA polymerase
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two forms of poxvirus
Single enveloped form – transmission to new host Double enveloped form – dissemination in the host. ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement, have their own DNA and RNA polymerase
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--- is used to vaccinate against small pox and monkey pox
vaccinia virus | unknown origin - cow pox? ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement, have their own DNA and RNA polymerase
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--- is poxvirus that effect sheep and goats
Orf virus ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement, have their own DNA and RNA polymerase
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---- is the pox virus that effects rabbits
Myxomavirus (myxomatosis) | do not infect humans ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement, have their own DNA and RNA polymerase
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the reservoir of monkeypox are
wild rodents | spread by contact ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement, have their own DNA and RNA polymerase
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---- is the reservoir for cowpox
wild rodent | can infect cats and humans
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orf virus causes --- symptoms
Lesions on lips, muzzle, feet, genitalia and teats can be spread to humans | poxvirus found in young goats and sheep ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement, have their own DNA and RNA polymerase
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two types of fowlpox
**drypox-** mechanically transmitted- papules on face and comb- heal in 3 weeks **wetpox- **aerosol transmission- generalized infection, lesions on lesion, can cause asphxiation, life long immunity ## Footnote poxvirus- large, complex, enveloped, ds DNA virus (class I), brick shaped, stable in environement, have their own DNA and RNA polymerase
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Drypox is spread by --- and cause ---
mechanically transmitted- papules on face and comb heal in 3 weeks | type of fowl pox
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wetpox is caused by ---
fowl pox aerosol transmission lesion in throat
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---- virus natural reservoir host (cottontail rabbits), it causes benign skin tumors
myxoma virus | type of rabbit pox
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myoxoma virus cause --- symptoms
generalized disease lethal in european rabbits spread by mosquitoes and fleas | rabbit pox
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ASFV
african swine fever virus | ASFARVIRIDAE ## Footnote asfarviridae- large, enveloped (lipid envelope, icosahedral capsid, 2nd lipid membrane), ds DNA virus (class I),very stable in environement, replicate in cytoplasm like pox virus
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where does asfarviridae replicate
in cytoplasm like pox virus ## Footnote asfarviridae- large, enveloped (lipid envelope, icosahedral capsid, 2nd lipid membrane), ds DNA virus (class I),very stable in environement, replicate in cytoplasm like pox virus
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2 life cycles of African swine fever virus
sylvatic cycle - pig→tick→wild boar →pig domestic cyle pig to pig ## Footnote asfarviridae- large, enveloped (lipid envelope, icosahedral capsid, 2nd lipid membrane), ds DNA virus (class I),very stable in environement, replicate in cytoplasm like pox virus
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sylvatic transmission of african swine fever
## Footnote asfarviridae- large, enveloped (lipid envelope, icosahedral capsid, 2nd lipid membrane), ds DNA virus (class I),very stable in environement, replicate in cytoplasm like pox virus
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human circoviruses
TT virus TTlike Mini Virus- TLMV >70% population, asymptomatic

Fall 22: micro (25 decks)

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