Skin drugs

Question 1

Tretinoin

Answer 1

Retinoic acid derivative
RAR/RXR agonist
-reduce sebum secretion
-anti inflammatory
—
-ance
—
-skin peeling from growth factors
-teratogenic (low therapeutic window)

Question 2

Isotretinoin

Answer 2

Retinoic acid derivative
RAR/RXR agonist
-reduce sebum secretion
-anti inflammatory
—
-ance
—
-skin peeling from growth factors
-teratogenic (low therapeutic window)

Question 3

Alitretinoin

Answer 3

Retinoic acid derivative
RAR/RXR agonist
-reduce sebum secretion
-anti inflammatory
—
-ance
—
-skin peeling from growth factors
-teratogenic (low therapeutic window)

Question 4

Tazarotene

Answer 4

Retinoic acid derivative
RAR/RXR agonist
-reduce sebum secretion
-anti inflammatory
—
-ance
—
-skin peeling from growth factors
-teratogenic (low therapeutic window)

Question 5

Bexarotene

Answer 5

Retinoic acid derivative
RXR selective
-Inhibits T-cells by blocking mitosis and increasing apoptosis
—
-T cell lymphoma
—
-teratogenic (low therapeutic window)

Question 6

Calcitriol

Answer 6

Vit D analogue (nuclear receptor agonist)
-lowers keratinocyte proliferation and life
-prevents T cell activation
—
-Psoriasis
—
-Hypercalcemia from osteoclasts
-skin irritation

Question 7

Calcipotriol

Answer 7

Vit D analogue (nuclear receptor agonist)
-lowers keratinocyte proliferation and life
-prevents T cell activation
—
-Psoriasis
—
-Hypercalcemia from osteoclasts
-skin irritation

Question 8

Tacalcitol

Answer 8

Vit D analogue (nuclear receptor agonist)
-lowers keratinocyte proliferation and life
-prevents T cell activation
—
-Psoriasis
—
-Hypercalcemia from osteoclasts
-skin irritation

Question 9

Salicylic acid

Answer 9

Keratolytic
-solubilized desmosomes
-activates hydrolytic enzymes
-increases water content of stratum corneum
—
-warts
—
-do not use on open wounds
-skin irritation

Question 10

Glycolic acid

Answer 10

Keratolytic
-solubilized desmosomes
-activates hydrolytic enzymes
-increases water content of stratum corneum
—
-warts
—
-do not use on open wounds
-skin irritation

Question 11

Imiquimod

Answer 11

Immune modulator
-binds toll like receptors on B cells
-increases inflammatory factor release
—
-anogenital warts
—
-skin irritation

Question 12

Cyclosporine

Answer 12

Immunosuppressant
-inhibits cyclophilin and calcineurin
—
-eczema or psoriasis
—
-nephrotoxicity
-hepatotoxicity
-hypertension

Question 13

Tacrolimus

Answer 13

immunosuppressant
-inhibit cyclophilin and calcineurin
—
-eczema or psoriasis
—
-hyper glycemic
-alopecia

Question 14

Pimecrolimus

Answer 14

immunosuppressant
-inhibit cyclophilin and calcineurin
—
-eczema or psoriasis
—
-hyper glycemic

Question 15

infliximab

Answer 15

/
anti body against TNF alpha
—
-psoriasis
—

Question 16

Adalimumab

Answer 16

/
antibody against TNGa
—-
-psoriasis

Question 17

Secukinumab

Answer 17

/
antibody against IL-17
—
-psoriasis
—

Question 18

Ixekizumab

Answer 18

/
antibody against homodimers of IL-17A
—
-psoriasis

Question 19

Hydrocortisone

Answer 19

Glucocorticoid (mild)
-decrease arachidonic mediator production via lipocortin expression
-mitosis inhibition
-vasoconstriction with topical AA
—-
-psoriasis
—
-Rebound from down regulated anti inflammatory mediators
-Skin thinning (mitosis inhibition)

Question 20

Clobetasol Propionate

Answer 20

Glucocorticoid (very potent)
-decrease arachidonic mediator production via lipocortin expression
-mitosis inhibition
-vasoconstriction with topical AA
—-
-psoriasis
—
-Rebound from down regulated anti inflammatory mediators
-Skin thinning (mitosis inhibition)

Question 21

Difucortolone valerate

Answer 21

Glucocorticoid (very potent)
-decrease arachidonic mediator production via lipocortin expression
-mitosis inhibition
-vasoconstriction with topical AA
—-
-psoriasis
—
-Rebound from down regulated anti inflammatory mediators
-Skin thinning (mitosis inhibition)