Bone disorders facts

Question 1

aminobisphosphonate MOA

Answer 1

inhibit osteoclasts via inhibition of mevalonate pathway which messes up signalling and causes apoptosis

Question 2

Non-aminobisphosphonates MOA

Answer 2

cause build up of cytotoxic agents in osteoclasts causing cell death

Question 3

Bisphosphonate contraindictions

Answer 3

-low blood calcium
-poor renal function

Question 4

selective estrogen receptor modulators (SERMs)

Answer 4

stimulate osteoblasts and inhibit osteoclasts

Question 5

PTH

Answer 5

low levels cause bone deposition
high levels cause bone reabsorption and renal elim of phosphates

Question 6

Vitamin D

Answer 6

regulator of calcium and phosphate works along side PTH

Question 7

Vitamin D receptor

Answer 7

intracellular receptors regulating gene transcription

Question 8

RANKL

Answer 8

Receptor activator of nuclear factor kappa ligand, binding to RANK increases osteoclast activity

Question 9

Calcitonin

Answer 9

When Ca gets too high can decrease retention and cause deposition binding directly to osteoclasts to inhibit them