Hepatitis and HIV drugs Flashcards
Lamivudine
Guanine analog
phosphorylated by cellular kinases inhibits RT
——-
-HBV and HIV
———
-resistance after 4y
Adefovir
/
Adenosine analog already with one phosphate. vDNA pol (RT) chain termination
——–
-HBV
-HIV, HSV, CMV
——-
-resistance after 5y
Tenofovir
/
adenosine analog with one phosphate. inhibits RT
—–
-HBV/HIV
Entecavir
/
Guanosine analog needing 3 phosphates, inhibitors RT
——
-HBV
Interferons
/
endogenous response to viral infection, induce cellular enzymes to inhibit viral protein synthesis
——
-HBV
——
-teratogenic
-flu like Sx
Ribavirin
nucleotide analog phosphorylated by host kinases
inhibits RNA pol with 3PO4
inhibits GTP synthesis in 1PO4
——–
-used as combo for HBV
——–
Mycophenolic acid
/
Inhibits IMP to XMP and thus GTP synthesis. lower GTP increases guanosine analog efficacy
——-
-HBV combo
——-
Grazoprevir
Inhibits NS3 protease which prevents viral protein splicing and therefore synthesis
Simeprevir
Inhibits NS3 protease which prevents viral protein splicing and therefore synthesis
Sofosbuvir
Uridine analog
RNA pol inhibitor phosphorylated then causing chain termination
Maraviroc
Entry inhibitor
binds to CCR5 to prevent entry
——
-HIV
Enfuvirtide
entry inhibitor
binds to gp41 glycoprotein and prevents entry
——
-HIV
Delavirdine
non-nucleoside reverse transcriptase inhibitor (NNRTIs)
They are allosteric modulators
——–
-only for HIV
Rilpivirine
non-nucleoside reverse transcriptase inhibitor (NNRTIs)
They are allosteric modulators
——-
-only for HIV
drugs ending in -navir
like protease inhibitors which prevent virus from becoming mature and functional
