Obesity facts

Question 1

obesity def.

Answer 1

BMI >30 kg/m^2

Question 2

NPY/AgRP neurons

Answer 2

Orexigenic neurons in hypothalamus, triggers feeding and decreases energy output

Question 3

POMC/CART neurons

Answer 3

anorexigenic neurons in hypothalamus, inhibit feeding and increases energy expenditure

Question 4

Positive feeding factors

Answer 4

Ghrelin, opioids, NPY, orexin

Question 5

negative feeding factors

Answer 5

Leptin, GLP-1, insulin, 5-HT

Question 6

Classification of obesity med

Answer 6

statistically significant placebo adjusted >5% loss in 1 year, or >35% lose >5% and double placebo

Question 7

GLP-1R receptor

Answer 7

in the hypothalamus Gs GCPR increasing cAMP and reducing feeding intake reducing adipose tissue

Question 8

5-HT2c receptor obesity

Answer 8

Increases POMC expression in hypothalamus to increase satiety signals

Question 9

GIP receptor

Answer 9

unknown how this effects obesity and it’s effects but shown to help either being agonized or antagonistic

Question 10

Glucagon receptor

Answer 10

Acted on by newer agents to increase base energy use to help burn fat