Antifungals drugs Flashcards
Amphotericin
Large macrolide
-Binds membrane concentrated by affinity for ergosterol and forms K+ channel
——–
-Anti fungal
——–
-hypotension
-renal toxicity (binds hepatocytes)
-hypokalemia
-thrombocytopenia
Nystatin
/
polyene antibiotic like amphotericin
——
-anti fungal
——-
-nausea
Griseofulvin
/
-inhibits fungal microtubules and prevents mitosis
——-
-narrow spectrum anti fugal
-Concentrates in keratinocytes (good for skin or nail infections
———
-photosensitivity
Caspofungin
Echinocandin drug
-inhibit 1,2 B- Glycan synthase which impairs wall integrity
——
-antifungal
——-
-rash
anidulafungin
Echinocandin drug
-inhibit 1,2 B- Glycan synthase which impairs wall integrity
——
-antifungal
——-
-rash
Micafungin
Echinocandin drug
-inhibit 1,2 B- Glycan synthase which impairs wall integrity
——
-antifungal
——-
-Hepatotoxicity
Ketoconazole
Azole drug
-inhibit fungal P450 3A to prevent ergosterol -> lanosterol preventing replication
———
-fungistatic anti fungal
———
-Gynecomastia
Fluconazole
Azole drug
-inhibit fungal P450 3A to prevent ergosterol -> lanosterol preventing replication
———
-fungistatic anti fungal
———
-Stevens-johnson syndrome
Itraconazole
Azole drug
-inhibit fungal P450 3A to prevent lanosterol -> ergosterol preventing replication
———
-fungistatic anti fungal
———
-Stevens johnson syndrome
Miconazole
Azole drug
-inhibit fungal P450 3A to prevent ergosterol -> lanosterol preventing replication
———
-fungistatic anti fungal
———
-Gynecomastia
Flucytosine
/
-Converted to 5-fluorouracil (fungi dependent) which inhibits thymidylate synthase
———
-anti fungal
-used with amphotericin to prevent resistance
——-
-Neutropenia
-alopecia
-Hepatitis
Terbinafine
-binds squalene epoxidase preventing squalene -> ergosterol
-Squalene build up is toxic
——-
-anti fungal
——-
-arthralgia
-myalgia
-hepatitis
Naftifine
-binds squalene epoxidase preventing squalene -> ergosterol
-Squalene build up is toxic
——-
-anti fungal
——-
-arthralgia
-myalgia
-hepatitis
