Bone disorders drugs Flashcards
Alendronate
Aminobisphosphonate
-inhibit mevalonate pathway causing osteoclast apoptosis
——–
-osteoporosis
-hypercalcemia
-bone cancer
-primary hyperPTH
———
-GI upset
-esophageal erosion
-breakdown of jaw bone
-flu like Sx with IV admin
Risedronate
Aminobisphosphonate
-inhibit mevalonate pathway causing osteoclast apoptosis
——–
-osteoporosis
-hypercalcemia
-bone cancer
-primary hyperPTH
———
-GI upset
-esophageal erosion
-breakdown of jaw bone
-flu like Sx with IV admin
Pamidronate
Aminobisphosphonate
-inhibit mevalonate pathway causing osteoclast apoptosis
——–
-osteoporosis
-hypercalcemia
-bone cancer
-primary hyperPTH
———
-GI upset
-esophageal erosion
-breakdown of jaw bone
-flu like Sx with IV admin
zoledronate
Aminobisphosphonate
-inhibit mevalonate pathway causing osteoclast apoptosis
——–
-osteoporosis
-hypercalcemia
-bone cancer
-primary hyperPTH
———
-GI upset
-esophageal erosion
-breakdown of jaw bone
-flu like Sx with IV admin
Etidronate
Non-aminobisphosphonate
-cause cytotoxic build up in osteoclasts
——–
-osteoporosis
-hypercalcemia
-bone cancer
-primary hyperPTH
———
-GI upset
-esophageal erosion
-breakdown of jaw bone
Clodronate
Non-aminobisphosphonate
-cause cytotoxic build up in osteoclasts
——–
-osteoporosis
-hypercalcemia
-bone cancer
-primary hyperPTH
———
-GI upset
-esophageal erosion
-breakdown of jaw bone
Raloxifene
selective estrogen receptor modulator
-simulate osteoblast, inhibit osteoclasts
——–
-osteoporosis in postmenopausal women who can’t take bisphosphonate
——–
-menopause like Sx
-thrombophlebitis
Teriparatide
PTH analogue
-increase Ca+, decrease PO4-
-can be anabolic if in low doses, building up bone
———-
-osteoporosis
-severe osteoporosis
-osteoporosis from Corticosteroid use
———
-hypercalcium
-leg cramps
-nausea
-vasodilation leading to postural hypotension
Calcitriol
Vit D analogue
-increases serum Ca+
——–
-osteoporosis
-hyperparathyroidism
-osteomalacia
-rickets
———
-hypercalcemia
-GI upset
-renal stones
ergocalciferol (D2)
Vit D analogue
-increases serum Ca+
——–
-osteoporosis
-hyperparathyroidism
-osteomalacia
-rickets
———
-hypercalcemia
-GI upset
-renal stones
Calcipotriene
Vit D analogue
-increases serum Ca+
——–
-osteoporosis
-hyperparathyroidism
-osteomalacia
-rickets
———
-hypercalcemia
-GI upset
-renal stones
Doxercalciferol
Vit D analogue
-increases serum Ca+
——–
-osteoporosis
-hyperparathyroidism
-osteomalacia
-rickets
———
-hypercalcemia
-GI upset
-renal stones
Paricalcitol
Vit D analogue
-increases serum Ca+
——–
-osteoporosis
-hyperparathyroidism
-osteomalacia
-rickets
———
-hypercalcemia
-GI upset
-renal stones
Denosumab
RANKL inhibitor
-prevents osteoclast activation
——–
-osteoporosis
——–
-eczema
-hypocalcemia
-infections
Salcatonin
IM/SC Calcitonin analogue
-decrease bone reabsorption and increase deposition
——–
-hypercalcaemia
-pagets disease
-postmenopausal or corticosteroid induced osteoporosis
——-
