2S [LEC]: Laboratory Assessments

Question 1

If excess is suspected, what type of dynamic function test is done?

Answer 1

Suppression

Question 2

If deficiency is suspected, what type of dynamic function test is done?

Answer 2

Stimulation

Question 3

In the diagnostic test for GH insufficiency, the patient is at a complete rest for how long before blood collection?

Answer 3

30 mins

Question 4

Best specimen for diagnostic test for GH insufficiency

Answer 4

Fasting serum

Question 5

Screening test for GH insufficiency

Answer 5

Physical activity test/ exercise test

Question 6

Confirmatory test or gold standard for GH insufficiency

Answer 6

Insulin tolerance test

Question 7

Normal pituitary response to insulin stress test

Answer 7

GH: >6 ug/L
Cortisol: >500 nmol/L

Question 8

Screening test for acromegaly

Answer 8

Somatomedin C or Insulin-Like growth factor-1 (IFG)

Question 9

Confirmatory test for acromegaly

Answer 9

Glucose Suppression Test/ OGTT

Question 10

Differentiates secondary and tertiary hypothyroidism

Answer 10

Thyrotropin releasing hormone (TRH) Stimulation Test

Question 11

In hyperthyroidism, what will be the level of TRH in Thyrotropin releasing hormone (TRH) Stimulation Test?

Answer 11

Flat (<2 mU/L)

Question 12

In hypothyroidism, what will be the level of TRH in Thyrotropin releasing hormone (TRH) Stimulation Test?

Answer 12

Exaggerated response (>25 mU/L)

Question 13

Used in the diagnosis of combined pituitary-thyroid disorders

Answer 13

Thyrotropin releasing hormone (TRH) Stimulation Test

Question 14

Assesses hypogonadism

Answer 14

GnRH test

Question 15

T/F: GnRH test can be done together with anterior pituitary function test

Answer 15

True

Question 16

Between LH and FSH, which hormone will be normally markedly increased in GnRH test in adults?

Answer 16

LH

Question 17

Between LH and FSH, which hormone will be normally markedly increased in GnRH test in children?

Answer 17

FSH

Question 18

Gold standard for the diagnosis of diabetes insipidus

Answer 18

Overnight water deprivation test/ concentration or dehydration test

Question 19

In overnight water deprivation test, what is the ideal start time?

Answer 19

10 PM

Question 20

How long is the WDT usually done?

Answer 20

8 hours

Question 21

Normal serum osmolality

Answer 21

275-295 mOsm/kg

Question 22

Normal urine osmolality

Answer 22

300-900 mOsm/kg

Question 23

Increased serum osmolality is an indication of what condition?

Answer 23

Diabetes insipidus

Question 24

Produced by the liver and to a lesser degree by skeletal muscles, primarily in response to growth hormone (GH) stimulation

Answer 24

Somatomedin C

Question 25

Somatomedin C helps doctor evaluate whether a person is producing a normal amount of which hormone?

Answer 25

Growth hormone

Question 26

Deficiency in this hormone can lead to lack of responsiveness to GH

Answer 26

IGF-1

Question 27

Screening test for adrenal insufficiencies

Answer 27

Cosyntropin test/ Tetracosactide test/ ACTH stimulation test

Question 28

ACTH dose in Tetracosactide test

Answer 28

250 ug IV, IM

Question 29

Confirms borderline response to ACTH stimulation test

Answer 29

Insulin tolerance test

Question 30

Gold standard for secondary adrenal insuficiency

Answer 30

Insulin Tolerance Test

Question 31

Used for the diagnosis of medullary carcinoma of the thyroid

Answer 31

Pentagastrin Stimulation Test

Question 32

A malignancy of the calcitonin-secreting cells of the thyroid gland

Answer 32

Medullary carcinoma of the thyroid

Question 33

Calcium level in patients with medullary carcinoma of the thyroid

Answer 33

Low (due to elevated calcitonin level)

Question 34

Sensitive indicator of endogenous cortisol

Answer 34

Urine free cortisol (UFC)

Question 35

Normal cortisol seen in urine

Answer 35

<2%

Question 36

Measures the amount of cortisol in the urine

Answer 36

Urine free cortisol (UFC)

Question 37

Plasma aldosterone level in saline suppression test if the patient has primary hyperaldosteronism

Answer 37

>10 ng/dL plasma aldosterone

Question 38

Plasma aldosterone level in saline suppression test in normal patient

Answer 38

<5 ng/dL plasma aldosterone