Lecture 25 - Glycolysis & Gluconeogenesis

Question 1

The reaction of glucose to \_\_\_\_\_\_\_ is governed by hexokinase.
Hexokinase is inhibited by \_\_\_\_\_\_\_\_\_\_\_\_.
A. G-6-P; G-6-P
B. G-6-P, F-1,6-BP
C. G-1-P, F-2,6-BP
C. F-1-P, ATP

Answer 1

A. G-6-P, G-6-P

Question 2

G-6-P to \_\_\_\_\_ is governed by phosphofructokinase. 
PFK is inhibited by \_\_\_\_\_\_\_ and \_\_\_\_\_.
A. F-1,6-BP, G-6-P
B. ATP, Citrate
C. AMP, F-2,6-BP
D. F-1,6-BP, AMP and F-2,6,BP

Answer 2

B. ATP, Citrate

Question 3

Pyruvate kinase catalyzes the reaction of PEP to \_\_\_\_\_. This reaction is inhibited by \_\_\_\_\_\_.
A. DHAP; F-2,6-BP and ATP
B. 3-PG; F-1,6-BP & Insulin
C. Pyruvate; Alanine, ATP, and Glucagon
D. Pyruvate; Insulin and F-1,6-BP

Answer 3

C. Pyruvate; Alanine, ATP, and Glucagon

Question 4

G-6-P to \_\_\_\_\_ is governed by phosphofructokinase. 
PFK is stimulated by \_\_\_\_\_\_\_ and \_\_\_\_\_.
A. F-1,6-BP, G-6-P
B. ATP, Citrate
C. AMP, F-2,6-BP
D. F-1,6-BP, AMP and F-2,6,BP

Answer 4

D. F-1,6-BP, AMP and F-2,6,BP

Question 5

Pyruvate kinase catalyzes PEP to pyruvate. This reaction is stimulated by:
A. F-2,6-BP and ATP
B. F-1,6-BP and Insulin
C. F-2,6-BP and insulin
D. F-1,6-BP

Answer 5

D. F-1,6-BP

Question 6

Insulin transporter in the brain; high glucose affinity
A. GLUT 1
B. GLUT 2
C. GLUT 3
D. GLUT 4

Answer 6

A. GLUT 1

Question 7

Main GLUT in neurons

A. GLUT 1
B. GLUT 2
C. GLUT 3
D. GLUT 4

Answer 7

C. GLUT 3

Question 8

Insulin dependent GLUT in skeletal m., heart, adipose.

A. GLUT 1
B. GLUT 2
C. GLUT 3
D. GLUT 4

Answer 8

D. GLUT 4

Question 9

Main GLUT in liver, low affinity without regulation.

A. GLUT 1
B. GLUT 2
C. GLUT 3
D. GLUT 4

Answer 9

B. GLUT 2

Question 10

Fructose can enter glycolysis at what location(s)?

A. G-6-P and F-1-P
B. DHAP and GAP
C. G-6-P and F-6-P

Answer 10

B. DHAP and GAP

Question 11

Translocation of this enzyme into the nucleus of hepatocytes helps stop glycolysis in the presence of low blood sugar.

Answer 11

Glucokinase (low insulin=low blood sugar=high glucagon)

Question 12

This is the rate limiting step of glycogen production

Answer 12

Glycogen synthase activity (addition of glucose to chain)

Question 13

Rate limiting step in glycogen breakdown

Answer 13

Glycogen phosphorylase activity (cleavage of glycogen)