Lecture 30 - Ox Phos Regulation Flashcards

1
Q

ATP Synthase is also known as “_______.”

A

Complex V

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2
Q

The F1 subunit of ATP synthase is comprised of:

A

alpha 3, beta 3, gamma, delta, and epsilon subunits

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3
Q

Wha F1 subunits are arranged in a hexameric ring?

A

alpha and beta

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4
Q

The ___ subunit of the hexameric F1 ring is catalytically active.

A

beta

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5
Q

Above the alpha and beta subunit ring, there exists a “stalk” that connects the F1 to the F0 subunits. What comprises this “stalk?”

A

gamma and epsilon proteins

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6
Q

Each ____ subunit in the F1 region has a distinct region connected to the stalk.

A

beta

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7
Q

Conformation of the __ subunits occurs as H+ flow through the ATP synthase.

A

beta

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8
Q

What are the three steps of ATP synthesis in the enzyme ATP synthase?

A

Binding of ADP + Pi (L conformation)
ATP synthesis (T conformation)
Release of ATP (O conformation)

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9
Q

The “O conformation” of the beta subunit release the newly synthesized ATP. What co-factors is required for this release?

A

H+

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10
Q

The “proton conducting unit” of the ATP synthase is the (F1/F0) region.

A

F0

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11
Q

The F0 region is comprised of what subunits?

A

The ring c subunits (8-14) and an a subunit.

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12
Q
This enzyme moves newly synthesized ATP from the matrix to the cytosol
A. ADP-ATP synthase
B. ATP synthase
C. Complex V
D. ATP-ADP translocase
A

D. ATP-ADP translocase

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13
Q

This prevents the hydrolysis of ATP by the reverse reaction of ATP synthase.

A

Inhibitory factor 1

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14
Q

ATP synthase can be uncoupled from oxidative phosphorylation by these proteins.

A

UCP 1 through 3

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15
Q

Uncoupling of ox-phos occurs in the _______, which is rich in mitochondria.

A. Brown adipose tissue
B. White adipose tissue
C. Principle cells of the kidney
D. Central nervous system

A

A. Brown adipose tissue

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16
Q
Allows for the inhibition of ATP synthase by binding to c-subunit
A. 2,4-DNP
B. Atractyloside
C. Bongkrekic acid
D. oligomycin
A

D. oligomycin

17
Q

Allows for uncoupling of ETC from ATP synthesis and dissipates the H+ gradient.

A. 2,4-DNP
B. Atractyloside
C. Bongkrekic acid
D. oligomycin

A

A. 2,4-DNP

18
Q

Inhibits ATP-ADP translocase

A. 2,4-DNP
B. Atractyloside
C. oligomycin

A

B. Atracyloside

19
Q

In addition to atractyloside, this also inhibits ATP-ADP translocase

A

bongkrekic acid

20
Q

Add something about “Increased matrix ATP levels” and tie it back to the inhibition of ATP-ADP translocase

A

Okay

21
Q

This is used to drive ATP Synthase

A. H+ gradient
B. ATP Synthase phosphorylase
C. UV radiation
D. ETC

A

A. H+ gradient