Vasodilators in Angina (Nitrates & Ca Blockers) Flashcards
If you have venous constriction, ______ blood gets back to the heart.
more
Activation of ß2 receptors on vasculature will lead to ________.
vasodilation (thus, ß-blockers lead to vasoconstriction)
While nitrates lower systolic volume and systemic pressure, they also __________ (an undesired effect).
increase heart rate
The -dipines (such as amlodipine) are ___________, while diltiazem and verapamil ___________.
→ dihydropyridine calcium-channel blockers that are pure vasodilators;
→ work on nodal cells, and so slow the HR
Calcium-channel blockers are eliminated ____________.
by CYP450
The vasodilators have side effects associated with ____________.
hypotension
What three things influence cardiac oxygen demand?
Heart rate, contractility, and myocardial wall tension
The main benefit ß-blockers have in angina is _________; however, they also __________.
decreasing heart rate to allow for more filling time; increase EDLVP
What is Prinzmetal angina?
Variant angina due to vasospasm
The dihydropyridine blockers are _______ acting.
fast
Other than hypotension, the dihydropyridine receptors have __________ as side effects.
flushing and edema
Ranolozine blocks _______ channels, which sometimes fail to inactivate in ischemic patients.
late sodium
Some patients can’t tolerate nitroglycerin because of headaches. If this happens, add ____________.
amlodipine
Nitroglycerin has ________ bioavailability.
low
Which type of ß receptor do ß-blockers bind to in the heart?
ß1
