Pathology of Nephritic Syndrome Flashcards
_______ of the convoluted tubules are in the cortex.
2/3
Most of the renal arterioles do not ____________, so a vascular event such as a thrombus can affect a large wedge of tissue.
anastamose
Only about __________ percent of the glomerulus should be cells. The rest should be open space.
20% - 30%
__________ is small enough to fit through the glomerular basement membrane, but it doesn’t (normally) do so because it is negatively charged.
Albumin
Crescents are indicative of an __________ process.
inflammatory
The hallmark of __________ is red-cell casts.
glomerular disease
Where does Tamm-Horsfall protein occur?
In the thick ascending loop of Henle
Crescents are proliferations of ___________.
podocytes
A hallmark of glomerular nephritis is _________ in the glomerulus.
PMNs
Differentiate focal, diffuse, global, and segmental.
Focal: some glomeruli are affected
Segmental: only parts of glomeruli are affected
Global: the entire glomerulus is affected
Diffuse: a lot of glomeruli are affected
What is immunofluorescence used for?
To detect deposits of antibody and their distribution
Thin basement membrane disease is not really ____________.
a problem; it can mimic a nephritic disease process, especially under stress like prolonged exercise
What is the triad of Alport’s disease?
Deafness
Nephritis
Ocular lesions
What is the inheritance pattern of Alport’s disease?
X-linked
Alport’s is due to a defect in ___________.
type IV collagen
