Actinomyces israelii Flashcards Preview

Microbiology Block 3 > Actinomyces israelii > Flashcards

Flashcards in Actinomyces israelii Deck (13):
1

Biology?

Branching filaments

 Gram +, 

Anaerobic

Sulfur granules

2

Transmission?

Dental work, inhalation, IUD

3

Pathogenesis?

- A break in the mucosal barrier is a pre-requisite for infection (OPPURTUNISTIC)

- forms a Chronic granulomatous lesions that become suppurate & form abscesses

- Resistance to ROS reactive oxygen species prevents killing by PMNs

- Bacteria form anaerobic anoxic abscess, which further protects replicating bacteria

4

Clinical Disease?

  • Actinomyces “Lumpy Jaw” Cervicofacial
  • Actinomyces Mycetoma
  • Pelvic actinomycosis
  • CNS actinomycosis

5

what history is important for Actinomyces “Lumpy Jaw” Cervicofacial?

Poor oral hygiene,

history of dental disease or oral trauma

6

Actinomyces Mycetoma will present with what?

Chronic subcutaneous infection

Usually in foot or lower leg

7

actinomyces israelii is part of what normal flora?

part of normal respiratory flora

8

what is characteristic of an actinomyces israelii infection?

sulfur granule (dense mass of bacteria surrounding PMNs)  seen in patient samples

A image thumb
9

is it acid-fast?

 

no

10

Does it contain mycolic acids in cell wall?

no

11

besides the sulfur granule, what else is characteristic of an infectino with actinomyce israelii?

foul smell

12

what is Pelvic actinomycosis?

what does it lead to?

- primary infection in a woman with IUD or sec infection from abdomen

- Vaginitis OR tissue destruction including tubo-ovarian abscesses or urethral obstruction

13

what is CNS actinomycosis?

solitary brain abscess or meningitis, subdural empyema