Salmonella (GNB strict pathogen) Flashcards Preview

Microbiology Block 3 > Salmonella (GNB strict pathogen) > Flashcards

Flashcards in Salmonella (GNB strict pathogen) Deck (30):
1

what biological feature is always present on salmonella?

  • Oxidase (-)*
  • Non-lactose Fermenting (white on MacConkey)**

2

what is salmonella enterica's biology?

  • Gram (-) bacilli
  • Facultative anaerobe
  • Capsule
  • Motile, peritrichous flagella*
  • Oxidase (-)**
  • Non-lactose fermenting***
  • H2S production****

3

what salmonella serotype will cause typhoid fever?

Salmonella enterica serovar Typhi or Paratyphi

4

what salmonella serotype will cause Gastroenteritis?

Non-typhoidal Salmonella 

5


what is the pathogenesis of salmonella?

Invades ileum IEC in addition to M cells via T3SS. 

 

6

how does salmonella avoid phagolysis?

Avoids phagolysis due to capsule.

 

7

Can salmonella live intracellularly?

yes, in macrophages

8

what is the biology of salmonella typhi?

  • Gram Negative Bacilli
  • Motile,
  • Non-fermenter,
  • H2S production

9

how does salmonella typhi spread?

fecal-oral (human restricted)

10

what is the Pathogenesis of salmonella typhi?

invades without inflammation and lives inside macrophages 

11

Salmonella Typhi can live permanently in what organ of the body?

gallbladder

12

what is the clinical presentation of typhoid fever?

  • High fever lasting >7days
  • Hepato-splenomegaly
  • Rash “Rose Spots” 
  • Headache

 

13

what patient history is important in order to diagnose typhoid fever?

travel especially to southeast asia

14

what complications can occur with typhoid fever?

1) septic death

2) asymptomatic chronic carrier 

15

what is the biology of non-typhoidal salmonella?

  • Gram Negative Bacilli
  • Motile,
  • Non-fermenter,
  • H2S production
  • Oxidase (-)*

16

what are the most common Non-typhoidal Salmonella?

S. Enteritidis and Typhimurium

17

how does non-typhoidal salmonella spread?

Zoonotic Reservoir 

 (found in animals)

poultry, pigs, reptiles

18

what is the Pathogenesis of non-typhoidal salmonella?

Invade ileum and  M cells

Crosses to lamina propria and triggers inflammation.

19

what immunity will activate to combat the non-typhoid salmonella?

cell mediated immunity

20

when does Non-typhoidal Salmonella become systemic?

cell mediated immunity compromised

21

what disease can non-typhoidal salmonella occur on a healthy host?

Mild Gastroenteritis = loose, watery stools

22

how common is non-typhoidal salmonella in USA?

very common

23

what will salmonellosis (non-typhoidal salmonella) cause in old age and children individuals?

  • Severe Gastroenteritis = high fever, watery/bloody stools
  • GI + Bacteremia = high fever, septic symptoms

24

what will salmonellosis (non-typhoidal salmonella) cause in the immunocompromised?

  • Typhoid Fever = high fever, septic symptoms
  • Meningitis = high fever, severe headache, etc.

25

what complications can arise with non-typhoidal salmonella?

  • Sepsis
  • Osteomyelitis **esp. sickle-cell patients
  • Septic Arthritis
  • Reactive Arthritis **HLA-B27 Patients

26

what tissues can Salmonella colonize? why?

any tissue because it can survive in macrophages!

27

what agar can help diagnose salmonella?

hatktoen agar (black colonies)

28

what treatment is given to salmonella on a healthy host?

Supportive treatment for NTS gastroenteritis in healthy host

29

what treatment is given to salmonella resistance?

Fluoroquinolones – Cipro

 

30

how is salmonella prevented? against biological structure will antibodies be made against?

Attenuated Live Strain Vaccine for S.Typhi ONLY 

 

against the capsule