what is shock?
Is generalized reduced perfusion ( hypoperfusion) of tissues with blood - which results in impaired oxygenation of tissues.
why does shock occur?
Reduced cardiac output
Reduced blood volume
Reduced vascular tone
shock can result in what?
hypotension -> impaired tissue perfusion -> cellular hypoxia -> multiple organ failure.
what are the different types of shock?
- Septic (endotoxic) shock*****
- Anaphylactic shock
what is Most common type of shock with highest mortality?
why does septic shock occur?
Due to overwhelming microbial infection
what microbe is the most common at causing septic shock? with what do they cause septic shock?
Gram negative septicemia*, Most cases caused by endotoxin producing gram-negative bacteria
what are all the most common causes of septic shock?
- E.coli sepsis (from indwelling urinary cathete)
- Urinary retention
- Spread of localized infection to blood stream:
what is the pathogenesis of septic shock?