Klebsiella pneumoniae Flashcards
what is the biology of klebsiella pneumoniae?
- Gram Negative Bacilli
- Lactose Fermenter-Purple Mucoid
- Encapsulated
where is klebsiella penumoniae normally found?
in the colon
how is klebsiella pneumoniae acquired nosocomially?
ventilators
who is most prone to acquiring klebsiella pneumoniae?
alchoholics
what protects klebsiella penumoniae from complement and opsonization, thus gains access to CNS?
the capsule
infection with klebsiella penumoniae will present with what clincally?
- UTI/Cystitis
- Pneumonia esp. D-VAP*
- Meningitis
how do you treat an infection with klebsiella penumoniae?
3rd Generation Cephalosporin
what resistance can klebsiella pneumoniae develop that makes it a major health threat?
Carbepenem-Resistance (CRKP)
what is the major virulence factor in the Klebsiella pneumoniae bacteria?
the capsule
how does klebsiella pneumoniae look like in MacConkey agar?
Purple-pink mucoid-colonies
what is an important clue to determining community-acquired klebsiella pneumoniae?
“Current grape jelly” purple viscous sputum
what is a clue to determining Nosocomial Ventilator-Associated Pneumonia (VAP)?
Delayed* presentation (~5-7 days after ventilator)
what is so bad about Carbepenase-Resistant Klebsiella (CRKP)?
it is multiple drug resistant
what is Plasmid-encoded carbapenase, found in carbepenemase-resistant klebsiella pneumoniae?
is a B-lactamase that degrades all B-lactams
