what is the biology of heamophilus?
Pleomorphic GNB *
what are the Medically imp. species of haemophilus?
- Haemophilus influenzae *
- H. ducreyi
- H. aegypticus
apart from pleomorphic, haemophilus can as well be identified other times in what shape?
fastidious haemophilus influenzae has 2 important factors?
Hemin (factor X) and NAD (factor V) *
what agar is used to identify haemophilus influenzae?
chocolate blood agar
where is haemophilus influenzae found normally in the body?
what strains of haemphilus are more virulent?
how does haemophilus influenzae spread?
what is the 2nd encapsulated strain of haemophilus influenzae?
what is the type B capsule made of?
polyribitol phosphate (PRP) *
what test used to diagnose type B haemophilus influenzae?
CSF antigen screens *
haemophilus influenza capsule is used for what purpose medically?
does H. influenzae have IgA protease *? what does it do?
yes; Degrades secretory IgA facilitating colonization of upper respiratory mucosa
Colonization of upper respiratory mucosa may lead to continous spread causing what?
- Sinusitis, otitis media
if h. influenzae becomes bacterimic, it will lead to what?
- Septic arthritis
what diseases does Haemophilus influenzae cause?
- Otitis media , Sinusitis *
- Bronchitis, Pneumonia * (NTHi)
- Meningitis *
- Epiglottitis * - Life-threatening emergency
- Septic arthritis
who is susceptible to meningitis due to h. influenzae?
unvaccinated children (3 months to 2 years)
what is a good way to confirm a meningitis diagnosis due to h. influenzae?
CSF gram stain * – showing gram negative coccobacilli
what is the treatment for meningitis due to h. influenzae?
what is the treatment for sinusitis due to h. influenzae?
what is the treatment for otitis media due to h. influenzae?
what two other haemophilus species are there?
H. aegyptius *
H. ducreyi *
what does H. aegyptius * cause?
purulent conjunctivitis, “pink eye”
what does H. ducreyi * cause?
Genital ulcers – “Chancroid”, an STD *
- Soft, painful ulcer
- Open lesions increase transmission of HIV
H. ducreyi caused genital ulcers are treated with what?
how does H. ducreyi spread?