Mycoplasma pneumoniae Flashcards Preview

Microbiology Block 3 > Mycoplasma pneumoniae > Flashcards

Flashcards in Mycoplasma pneumoniae Deck (14):
1

biology?

Smallest free living organism

No cell wall or peptidoglycan (so poor gm stain)

Cell membrane has cholesterol

anaerobe

Non-motile

2

how does it look on  Eaton’s agar?

“Fried egg” colonies

3

what does it need to grow?

cholesterol

4

Epidemiology?

Human-to-human aerosol transmission

5

MCC  of what?

Community-acquired atypical pneumonia 

6

what is characteristic of the tip organelle of mycoplasma?

Multiple adhesion factors are located

highly specialized to tightly adhere to host epithelium

7

Pathogenesis?

  • Tip organelle orients to attach to epithelial cell surface in respiratory track.
  • Attachment causes cilia arrest, leading to epithelial cell necrosis
  • Bacteria are able to replicate using released cell components (cholesterol)
  • Very little inflammation (no cell wall components!)
  • Cell membrane resembles host because of cholesterol so triggers auto-reactive antibodies

 

8

how do you know the person is a Chronic carrier?

 coughing with no fever

9

Clinical Disease of Mycoplasma?

“Walking Pneumonia”

10

how does walking pneumonia present?

  • Non productive (no exudate) Long lasting cough (2-3 weeks)
  • X-ray shows small areas of infection or “Patchy infiltrates” with no leukocytes

11

what differentials or other diseases can also look like walking pneumonia?

  • Viral pneumonia
  • Chlamydia pneumoniae*

12

Patients develop self-reactive antibodies against what?

how is it measured?

cholesterol (anti-RBC), which are measured with cold agglutinin test.

13

what is the treatment for mycoplasma?

Macrolides: Erythromycin

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