Smallest free living organism
No cell wall or peptidoglycan (so poor gm stain)
Cell membrane has cholesterol
how does it look on Eaton’s agar?
“Fried egg” colonies
what does it need to grow?
Human-to-human aerosol transmission
MCC of what?
Community-acquired atypical pneumonia
what is characteristic of the tip organelle of mycoplasma?
Multiple adhesion factors are located
highly specialized to tightly adhere to host epithelium
- Tip organelle orients to attach to epithelial cell surface in respiratory track.
- Attachment causes cilia arrest, leading to epithelial cell necrosis
- Bacteria are able to replicate using released cell components (cholesterol)
- Very little inflammation (no cell wall components!)
- Cell membrane resembles host because of cholesterol so triggers auto-reactive antibodies
how do you know the person is a Chronic carrier?
coughing with no fever
Clinical Disease of Mycoplasma?
how does walking pneumonia present?
- Non productive (no exudate) Long lasting cough (2-3 weeks)
- X-ray shows small areas of infection or “Patchy infiltrates” with no leukocytes
what differentials or other diseases can also look like walking pneumonia?
- Viral pneumonia
- Chlamydia pneumoniae*
Patients develop self-reactive antibodies against what?
how is it measured?
cholesterol (anti-RBC), which are measured with cold agglutinin test.
what is the treatment for mycoplasma?