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Microbiology Block 3 > Zoonotic GNB > Flashcards

Flashcards in Zoonotic GNB Deck (52)
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1

what are the gram negative bacilli zoonotic bacteria?

  1. Pasteurella 
  2. Yersinia pestis
  3. Francisella
  4. Brucella
  5. Bartonella

2

Pasteurella multocida

3

how does pasteurella multocida look like?

coccobacilli GNB

4

how does pasteurella multocida spread?

Transmission: bites of animals, cat bites *

 

5

pasteurella multocida will cause what?

Cellulitis with lymphadenitis

Wound infections

 

6

treatment for pasteurella multocida?

Amoxicillin-clavulanate *

 

7

Yersinia pestis

8

where in the US is yersinia pestis can be seen?

desert southwest

9

what is the biology of yersinia pestis?

  • Oxidase negative, 
  • lactose non-fermenting
  • Bipolar staining, 
  • “safety-pin” *
  • Facultative intracellular pathogen

 

10

how is yersinia pestis acquired?

through animals only

11

in urban areas, what animal can carry yersinia pestis?

RATS *

12

IN US - desert southwest, what animal can carry yersinia pestis?

  • Wild rodents *
  • Prairie-dogs,
  • ground squirrels,
  • chipmunks,
  • other wild rodents *

13

how does yersinia pestis transmit to a human?

  • Bites of infected FLEAS *(animal-to-animal, Animal-to-human)
  • Respiratory droplets  (person-to-person spread *)
  • Direct handling * of tissue/body fluids of infected animals

14

what is the pathogenesis of yersinia pestis?

  • phagocytosed by PMNs, monocytes
  • resist killing and multiply
  • Death of infected phagocytes and release of organisms; multiply extracellularly in lymph node 
  • Regional lymph nodes  enlarged (“BUBOES” Bubonic plague*)
  • spread to bloodstream
  • dissemination to lungs (Pneumonic plague *), meninges (Plague meningitis), septicemia and septick shock (Plague septicemia)

 

15

what symptoms does yersinia pestis cause?

  • One/more enlarged lymph nodes – “Buboes"
  • Femoral/inguinal/axillary/cerivcal lymph nodes

16

how do you prevent dissemination of yersinia pestis?

Early treatment prevents dissemination and development of pneumonic plague and other system infections *

 

17

how does pulmonary dissemination spread?

transmits to other human through respiratory droplets

18

if pulmonary plague is left untreated what happens?

bubonic/septicaemic plague

19

what symptoms is seen in Pneumonic plague *?

 

cough with bloody or watery mucous

 

20

how infectious is Pneumonic plague *?

 

Highly infectious *

 

21

Rapid spread of disease occurs where?

 in communities 

22

how do you know you have Septicemic plague?

you will see: 

- Septic shock

- Bleeding under skin, other tissues (ecchymoses)         - blackening of fingers, toes, nose*

 

23

how do you confirm a diagnosis of plague?

  • Giemsa stain – you see bipolar rods *
  • Direct Fluorescent antibody (DFA) test *

24

how do you treat yersinia pestis?

Aminoglycosides

25

Tularemia (Francisella tularensis)

26

what is Francisella tularensis biology?

Facultative intracellular pathogen

27

what animals carry francisella tularensis?

rabbits, deer, rodents *

 

28

how can you acquire francisella tularensis?

  • Bite of arthropod vector
  • Traumatic implantation – eg. While skinning rabbits *
  • Inhalation of aerosols – skinning animals *

29

who is most prone to acquiring francisella tularensis?

Veterinarians, hunters, trappers *

 

30

what dieseases will francisella tularensis cause?

  • Ulceroglandular disease:  local ulcer + swollen regional LN *
  • Glandular: swollen lymph nodes
  • Oculoglandular: inflammation of eyes + swollen LN front of ear
  • Oropharyngeal: sore throat, mouth ulcers, swollen neck glands
  • Pneumonic: Cough, chest pain, difficulty breathing