Mycobacteria leprae Flashcards Preview

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Flashcards in Mycobacteria leprae Deck (14):
1

Biology?

Prefer lower temp 

obligate anaerobe

acid-fast

facultative intracellular

mycolic acid cell wall

2

2 forms of leprae?

which is more severe?

Tuberculoid = Less severe

Lepromatous = More severe

3

what cells does m. leprae target?

dermal macrophages and Schwann cells of peripheral nerves

4

2 disease manifestations occur due to what response?

 Th1 or Th2

5

m. leprae with high Th1 will be?

tuberculoid leprae

6

m. leprae with high Th2 will be?

lepromatous

7

what immunity will be highly responding to tuberculoid leprosy?

Cell mediated because its Th1

8

what immunity will be highly responding to lepromatous leprosy?

humoral immunity because it is Th2

9

what lesions are seen in tuberculoid leprosy?

Flat macular lesions

10

what lesions are seen in lepromatous leprosy?

Raised papular lesions

11

which leprosy will lead to a presentation of loss of feeling?

both

12

what are the symptoms of tuberculoid leprosy?

  •  Maculoanasethetic patch with hypopigmented centre. 
  • Skin is dry, hairless & insensitive.

13

what symptoms wil be seen with Lepromatous Leprosy?

  • Glistening erythematous or skin-colored papules, nodules & plaques.
  • Ears: Thickened & nodular.
  • Legs: Edema & ulceration.

14