Prefer lower temp
mycolic acid cell wall
2 forms of leprae?
which is more severe?
Tuberculoid = Less severe
Lepromatous = More severe
what cells does m. leprae target?
dermal macrophages and Schwann cells of peripheral nerves
2 disease manifestations occur due to what response?
Th1 or Th2
m. leprae with high Th1 will be?
m. leprae with high Th2 will be?
what immunity will be highly responding to tuberculoid leprosy?
Cell mediated because its Th1
what immunity will be highly responding to lepromatous leprosy?
humoral immunity because it is Th2
what lesions are seen in tuberculoid leprosy?
Flat macular lesions
what lesions are seen in lepromatous leprosy?
Raised papular lesions
which leprosy will lead to a presentation of loss of feeling?
what are the symptoms of tuberculoid leprosy?
- Maculoanasethetic patch with hypopigmented centre.
- Skin is dry, hairless & insensitive.
what symptoms wil be seen with Lepromatous Leprosy?