Acute leukemia Flashcards Preview

Year 2 Hematology > Acute leukemia > Flashcards

Flashcards in Acute leukemia Deck (14)
1

what are the exposure related etiologies for acute leukemia?

1. chemicals
2. radiation
3. tobacco
4. chemotherapy

2

is organomegaly common in AML?

no

3

what is an Auer rod?

fused lysosomes and neutrophilic granules with enzymes and crystalline inclusions

4

what structure is pathognomonic for AML?

Auer rod

5

where is bone marrow usually taken?

posterior iliac crest

6

what is the treatment for AML in patients under 60 years of age?

7 plus 3

7 days of cytarabine, 3 days of daunorubicin

obliterates bone marrow

7

what is involved in the AML induction support?

1. irradiation of all blood products
2. platelets
3. prophylactic abx

8

what is tumor lysis syndrome?

uric acid shower following death of logs of cells

9

what is the cause of APL?

1. chromosome translocation t(15,17)
2. fusion of PML/RARa
3. inhibits transcription of genes involved in promyelocytic differentiation

10

what is the treatment for APL?

1. all trans-retinoic acid (ATRA) - maturation agent
2. 7 plus 3 induction

11

what is a major adverse effect involved with APL?

DIC

12

what is the treatment for ALL in adults?

1. induction chemotherapy
2. bone marrow transplantation

13

in which acute leukemia does maintenance therapy have a role?

ALL

14

what is the presentation for CML?

1. easy bleeding
2. easy bruising
3. fever
4. weight loss
5. LUQ pain
6. night sweats