Flashcards in Pathology of lymphomas Deck (23)
follicular lymphomas are composed of what cell types?
follicle germinal center cells - centroblasts and centrocytes
follicular lymphoma is positive for what main markers?
follicular lymphoma is negative for what markers?
how does mantle cell lymphoma present?
male, 5th to 6th decade
mantle cell lymphoma is positive for what main markers?
CD5, cyclin D1
mantle cell lymphoma is negative for what markers?
all patients with Burkitt lymphoma are at risk of disease involvement with which system?
what is the morphology of Burkitt lymphoma?
1. diffuse monomorphic infiltrate of intermediate sized round to slightly irregular lymphoid cells with multiple peripherally placed nucleoli
2. tingible body macrophages ("starry sky")
what is a tingible body macrophage? where are they normally found?
1. contains phagocytized, apoptotic cells in various states of degradation
2. germinal centers
Burkitt lymphoma is positive for which markers?
CD10, CD19, CD20
Burkitt lymphoma is negative for which markers?
what is the cause of adult T cell leukemia / lymphoma?
human T cell leukemia virus type 1 (HTLV-1) retrovirus
adult T cell leukemia often presents with what condition?
adult T cell leukemia is a neoplastic proliferation of what cell type?
CD4 positive T cells
flower cells are indicative of what condition?
adult T cell leukemia
what is the morphology of mycosis fungoides?
cerebriform nuclei - folded nuclear membrane
what are the phases of mycosis fungoides?
plaque and tumor phases
what is the morphology of T cell ALL?
1. monotonous population of blasts
2. may have more clumped chromatin
3. sheets of blasts in lymph node, soft tissue, BM
T cell ALL is positive for what markers?
CD34, TdT, CD1a, cytoplasmic CD3
anaplastic large cell lymphoma is positive for what marker in younger patients?
ALK-1 (anaplastic lymphoma kinase 1)
what is the morphology of anaplastic large cell lymphoma?
pleomorphic with characteristic "Hallmark" cells:
2. abundant cytoplasm
3. kidney shaped nuclei
4. paranuclear eosinophilic region
anaplastic large cell lymphoma is positive for what markers?
CD30 and ALK