Pathology of lymphomas Flashcards Preview

Year 2 Hematology > Pathology of lymphomas > Flashcards

Flashcards in Pathology of lymphomas Deck (23)
1

follicular lymphomas are composed of what cell types?

follicle germinal center cells - centroblasts and centrocytes

2

follicular lymphoma is positive for what main markers?

CD10, Bcl-2

3

follicular lymphoma is negative for what markers?

CD5, CD3

4

how does mantle cell lymphoma present?

male, 5th to 6th decade

5

mantle cell lymphoma is positive for what main markers?

CD5, cyclin D1

6

mantle cell lymphoma is negative for what markers?

CD23, CD3

7

all patients with Burkitt lymphoma are at risk of disease involvement with which system?

CNS

8

what is the morphology of Burkitt lymphoma?

1. diffuse monomorphic infiltrate of intermediate sized round to slightly irregular lymphoid cells with multiple peripherally placed nucleoli
2. tingible body macrophages ("starry sky")

9

what is a tingible body macrophage? where are they normally found?

1. contains phagocytized, apoptotic cells in various states of degradation
2. germinal centers

10

Burkitt lymphoma is positive for which markers?

CD10, CD19, CD20

11

Burkitt lymphoma is negative for which markers?

Bcl-2

12

what is the cause of adult T cell leukemia / lymphoma?

human T cell leukemia virus type 1 (HTLV-1) retrovirus

13

adult T cell leukemia often presents with what condition?

hypercalcemia

14

adult T cell leukemia is a neoplastic proliferation of what cell type?

CD4 positive T cells

15

flower cells are indicative of what condition?

adult T cell leukemia

16

what is the morphology of mycosis fungoides?

cerebriform nuclei - folded nuclear membrane

17

what are the phases of mycosis fungoides?

plaque and tumor phases

18

what is the morphology of T cell ALL?

1. monotonous population of blasts
2. may have more clumped chromatin
3. sheets of blasts in lymph node, soft tissue, BM

19

T cell ALL is positive for what markers?

CD34, TdT, CD1a, cytoplasmic CD3

20

anaplastic large cell lymphoma is positive for what marker in younger patients?

ALK-1 (anaplastic lymphoma kinase 1)

21

what is the morphology of anaplastic large cell lymphoma?

pleomorphic with characteristic "Hallmark" cells:

1. medium
2. abundant cytoplasm
3. kidney shaped nuclei
4. paranuclear eosinophilic region

22

anaplastic large cell lymphoma is positive for what markers?

CD30 and ALK

23

mycosis fungoides is a neoplastic proliferation of what cell type?

CD 4 positive T cells