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Year 2 Hematology > Pathology of anemia > Flashcards

Flashcards in Pathology of anemia Deck (13)
1

definition: anemia

decreased RBC mass affecting tissue oxygenation

2

in H&E staining, do immature RBCs stain darker or lighter?

darker - more RNA

3

normoblastic RBCs will be seen in what type of anemia?

hemolytic

4

what are the morphological features of spherocytes?

small, round, no central pallor

5

what conditions could cause the presence of spherocytes?

1. hereditary spherocytosis
2. autoimmune hemolytic anemia

6

definition: schistocyte

RBC fragment

7

in what conditions could schistocytes be present?

1. microangiopathic hemolytic anemia (DIC, TTP, HUS)
2. other hemolytic anemias

8

what are the causes of basophilic stippling / punctate basophilia?

1. lead poisoning (coarse stippling)
2. severe anemia
3. severe infection
4. drug exposure
5. alcoholism

9

what are howell jolly bodies?

nuclear remnants (larger than basophilic stippling)

10

what is the cause of howell jolly bodies?

1. absence of spleen
2. hemolysis

11

what are the common causes of macrocytic anemia?

1. B12 / folate deficiency
2. alcohol use
3. liver disease
4. reticuloccytosis

12

what is the pathogenesis of macrocytic anemia?

1. defective DNA synthesis (B12/folate deficiency)
2. increased RBC membrane (lipid alterations - alcohol use)

13

what is the reason for low PCV in patients with blood loss anemia?

intravascular shift of water from interstitial fluid compartment - hemodilution