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Year 2 Hematology > Anemia II > Flashcards

Flashcards in Anemia II Deck (17)
1

the pathophysiology classification of anemia is based on what factor?

reticulocyte response (RR)

2

what are the main general causes for normocytic anemia?

1. decreased production
2. increased destruction

3

what are the main reasons for megaloblastic anemia?

1. B12 or folate deficiency
2. drug related

4

what are the high risk groups for B12 deficiency?

1. women over 60
2. African and Asian countries

5

what is the most common cause of B12 deficiency? what are the causes?

1. pernicious anemia
2. autoantibodies against IF or atrophy of cells that produce IF

6

what are the neuro findings for B12 deficiency?

1. paresthesias
2. ataxia
3. change in mental status

7

what are the physical exam findings for B12 deficiency?

1. decreased position and vibratory sense
2. vision, taste, smell problems
3. positive Romberg's sign
4. Babinski's sign
5. neuropathy

8

what will be seen on diagnostic labs for B12 deficiency?

1. low B12
2. high serum methylmalonic acid
3. high homocysteine

9

hypersegmented neutrophils could be indicative of what condition?

B12 deficiency

10

what electrolyte must be closely monitored during treatment for B12 deficiency?

potassium

11

what are the diagnostic labs for pernicious anemia?

1. parietal cell and IF Ab test (positive)
2. serum gastrin level (high)
3. serum pepsinogen level (low)
4. gastric biopsy (atrophy)

12

what is the cause of aplastic anemia?

bone marrow failure caused by suppression or injury to the stem cells (bone marrow fails to produce mature blood cells)

13

what is the result of aplastic anemia?

pancytopenia

14

how will patients with aplastic anemia present?

1. petechiae
2. weak, fatigued
3. bacterial infections (neutropenia)

15

what diagnostic labs should be performed for aplastic anemia?

1. pancytopenia
2. bone marrow biopsy (hypocellular)

16

what will homocysteine levels look like in folate deficiency?

high

17

what will the CBC look like in patients with aplastic anemia?

1. anemia
2. neutropenia
3. thrombocytopenia
4. hypcellular bone marrow