Thrombosis Flashcards Preview

Year 2 Hematology > Thrombosis > Flashcards

Flashcards in Thrombosis Deck (16)
1

virchows triad

1. endothelial injury
2. blood stasis / turbulent blood flow
3. hypercoagulability

2

what are that anti platelet effects of the endothelium?

1. non activated platelets do not adhere
2. PGI2 and NO prevent platelet adhesion

3

what are the anticoagulant properties of the endothelium?

1. heparin like molecule activates antithrombin III
2. thrombomodulin binds thrombin which activates protein C

4

what are the fibrinolytic properties of the endothelium?

synthesis of TPA

5

what are the prothrombotic properties of the endothelium?

1. vWF
2. tissue factor
3. plasminogen activating factor

6

what are the four fates of a thrombus?

1. propagation (progression)
2. embolization
3. lysis
4. organization and recanalization

7

what is the most common cause of preventable hospital death?

PE

8

what is an important consideration for factor V Leiden disease?

gene dose

9

what is the effect of oral contraceptives on factor V Leiden disease?

highly increased

10

what are the common inherited thrombophilias?

1. antithrombin deficiency
2. protein C deficiency
3. protein S deficiency
4. factor V Leiden

11

what are the features of antithrombin III deficiency?

1. autosomal dominant
2. thrombotic phenomena in adolescence
3. PE is usually first sign

12

what are the features of protein C deficiency?

1. autosomal dominant and recessive
2. skin necrosis when warfarin is introduced

13

what are the features of protein S deficiency?

1. autosomal dominant
2. skin necrosis when warfarin is introduced
3. usually presents as an infant

14

pathogenesis of factor V Leiden

1. protein C mutation
2. slows inactivation of factor Va by protein C

15

what are the therapeutic options for thrombocytopenia?

1. unfractionated heparin
2. LMW heparin
3. coumadin
4. aspirin
5. Gp IIb / IIIa inhibitors

16

one thrombotic event increases future risk by how much?

5-8