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Year 2 Hematology > Clinical interpretation of lab exams > Flashcards

Flashcards in Clinical interpretation of lab exams Deck (25)
1

definition: anisocytosis

RBC size

2

definition: poikilocytosis

RBC morphology

3

normal volume of RBC

80-100 fL

4

on the basis of MCV RBCs can be divided into what categories?

1. microcytic
2. macrocytic
3. normocytic

5

on the basis of etiology RBCs can be divided into what categories?

1. blood loss
2. impaired production
3. increased destruction

6

reticulocyte counts are used to assess what?

erythropoietic activity

7

what is the ESR used for?

if disease is active or not (underlying organic disease)

8

the initial reticulocyte % must be corrected for what factor?

degree of anemia

9

what is the formula for corrected reticulocyte count?

(patient Hct/45) x reticulocyte count

10

what is the normal corrected reticulocyte count value?

3%

11

what are the four main causes of microcytic anemia?

1. iron deficiency (most common)
2. anemia of chronic disease (renal failure)
3. thalassemia
4. sideroblastic anemia (least common)

12

what are the lab tests for microcytic anemia?

1. serum iron
2. serum TIBC
3. % saturation (serum Fe/TIBC)x100
4. serum ferritin

13

what is the single best test for iron storage?

serum ferritin

14

what is the gold standard for diagnosing B thalassemia?

Hb electrophoresis

15

how will serum ferritin look for IDA?

low

16

how will serum ferritin look for ACD?

normal or increased

17

how is blood treated for a direct Coomb's test?

patient RBCs are pre-treated with antibody

18

lymphoma

lymphoid neoplasms arising as discrete mass

19

leukemia

lymphoid neoplasms with involvement of blood and bone marrow

20

what is the only way to determine if a WBC is coming fro T cell or B cell lineage?

immunophenotyping (IHC, flow cytometry)

21

what is the immunophenotyping marker for B cells?

CD20

22

what is the immunophenotyping marker for T cells?

CD3

23

what is the major blood cancer for patients younger than 10 years of age?

acute leukemia

24

what is the major blood cancer for patients between 10 and 19 years of age?

lymphoma

25

what are the lymphoma staging criteria?

I. single lymph node region or extralymphatic site
II. two or more LN regions or extralymphatic site on same side of diaphragm
III. LN regions or extralymphatic site on both sides of diaphragm
IV. disseminated or diffuse involvement of one or more extralymphatic sites

A - asymptomatic
B - fever, night sweats, or more than 10 lb weight loss