Flashcards in Blood components Deck (22)
are older RBC units better or worse than newer units?
no differences in clinical outcome
are restrictive or liberal transfusion strategies better for Hb transfusion?
what is the Hb transfusion threshold for symptomatic patients with an MI?
10 g/dL or less
what is the Hb transfusion threshold for hospitalized patients?
what virus is carried in WBCs?
leukoreduced units are considered free of what disease?
what is done to prevent transfusion associated graft-vs-host disease?
which population is indicated for receiving irradiation of cellular blood components for prevention of GVHD?
immunocompromised HSC recipients or organ transplant recipients
when is RBC volume reduction performed?
when circulatory overload is a concern (CHF, renal failure)
what are the indications for giving plasma?
1. coagulation factor replacement
2. massive transfusions
what is platelet refractoriness?
when patients who have received platelets make antibodies to the transfused platelets
how are compatible platelets found for patients with platelet refractoriness?
1. give random platelet units
2. cross match
3. find platelets that do not have the antigen that the antibody is directed toward
what is in cryoprecipitate?
1. factor VIII
4. factor XIII
when is cryoprecipitate used?
1. fibrinogen replacement in bleeding patient
2. when normal treatment medications are not available (hemophilia A, factor XIII, vWF disease)
what is included in the prothrombin complex concentrate? when is it given?
1. vitamin K factors (10, 9, 7, 2)
2. patients with hemophilia during hemorrhage, perioperative bleeding management, routine prophylaxis of bleeding events
when is recombinant factor VIII given?
patients with hemophilia A
when are IV Igs given?
1. primary humoral immunodeficiencies
2. immune thrombocytopenia
3. chronic inflammatory demyelinating polyneuropathy
5. post exposure prophylaxis
when is albumin given?
2. volume replacement
what is the reason for coagulation abnormalities following a massive transfusion?
replacement of blood loss with pRBCs and crystalloids and colloids will lead to a dilution of coagulation factors
how do coagulation abnormalities manifest in test values following a massive transfusion?
1. increased PT and aPTT
2. fibrinogen levels drop - give cryoprecipitate
what is a directed donation?
1. donation of a component for a specific patient
2. risky for both donor and patient (donor may be untruthful)