Immunohematology Flashcards Preview

Year 2 Hematology > Immunohematology > Flashcards

Flashcards in Immunohematology Deck (31)
1

RBC carbohydrate antigens tend to stimulate what type of Ig?

IgM

2

RBC protein antigens tend to stimulate what type of Ig?

IgG

3

which Ig can cross the placenta? which Ig cannot?

1. IgG
2. IgM

4

which RBC antigen forms the building block for a person to be any blood type other than O?

H antigen

5

what is the Bombay phenotype?

lack of H antigen on RBCs

6

if you have just the H antigen, what blood type must you be?

O

7

what is the universal donor for transfusing RBCs? why?

O - only H antigens

8

which blood group forms neither A nor B antibodies?

AB

9

what is the rarest blood type?

AB

10

what is the main antigen of the Rh system?

D

11

how does hemolytic disease of the fetus and newborn work?

1. mom is Rh negative
2. baby is Rh positive
3. mom makes antibodies to D antigen for first pregnancy
4. upon second pregnancy, D antibodies attack the D antigens on baby's RBCs

12

what is RhoGAM? what does it do?

1. anti-D Ab given to mother prior to first birth
2. removes D positive RBCs from baby before immune system forms antibodies

13

what is front type?

commercially made antisera that is mixed with patient RBCs to determine anti-A/B phenotype

14

what is back type?

commercially made RBCs that are mixed with patient plasma to determine presence of anti-A or anti-B antibodies

15

what tests are required for confirmation of blood type?

front type and back type

16

what does the direct antiglobulin test (direct Coomb's test) detect? what type of sample is used?

1. in vivo auto or alloantibody sensitization - IgG and/or complement on RBCs
2. patient RBCs are used

17

what is a common cause of a positive DAT?

medications

18

what does the indirect antiglobulin test (indirect Coomb's test) detect? what type of sample is used?

1. detects in vitro antibody sensitization - unexpected Abs, cross matching
2. uses patient serum / plasma mixed with random donor RBCs

19

a D positive patient can receive which Rh blood types?

D positive or D negative

20

a D negative patient can receive which Rh blood types?

only D negative (except in emergencies)

21

what type of RBCs can a type A patient receive?

A and O

22

what type of RBCs can a type B patient receive?

B and O

23

what type of RBCs can a type AB patient receive?

AB, A, B, and O

24

what type of RBCs can a type O patient receive?

only O

25

what is the universal donor for plasma?

AB

26

what type of plasma can a type A patient receive?

A and AB

27

what type of plasma can a type B patient receive?

B and AB

28

what type of plasma can a type AB patient receive?

AB

29

what type of plasma can a type O patient receive?

O, A, B, and AB

30

what % of people who are D negative and given D positive blood will develop the anti-D Ab?

50-70%

31

what is the universal blood type recipient?

AB