Flashcards in Microcytic anemia Deck (18)
what does a small RDW (red cell distribution width) mean?
non heme iron is mostly present in what forms?
sulfate and gluconate
iron is best absorbed in what pH environment?
what is the role of hepcidin?
shuts down iron transporter (ferroportin) on duodenal cell, reducing the amount of available iron for circulation
which cells produce EPO?
where is most of the iron storage in the body located?
what lab values will you see with iron deficiency anemia?
1. low Hb/Hct
2. low MCV
3. low ferritin (accurate measurement)
4. low transferrin saturation
5. high TIBC
what are the symptoms of IDA?
1. pica / pagophagia
2. restless leg syndrome
3. pallor / pale palmar creases / pale conjunctiva
5. nail changes
what is the key player in anemia of chronic disease?
hepcidin (an acute phase reactant)
is anemia of renal disease usually hypochromic, hyperchromic, or normochromic?
what is the mechanism for anemia of renal disease?
1. renal fibroblasts don't make EPO
2. bone marrow is not stimulated
target cells are very common in what conditions?
alpha and beta thalassemia
why is there no alpha globin made in B thalassemia?
because you do not have beta subunits - you are producing mostly gamma and delta
what are the clinical features of B thalassemia?
1. increased RBC destruction
2. iron overload in RES
3. anemia, hypermetabolic marrow
4. therapeutic phlebotomy
5. transfusion requirement
what is the characteristic finding in sideroblastic anemia?
ring sideroblast in the marrow
what is the pathogenesis of sideroblastic anemia?
RBCs are not making efficient use of the iron because they are missing a lot of porphyrin rings
congenital sideroblastic anemia usually involves what deficiency?