Microcytic anemia Flashcards Preview

Year 2 Hematology > Microcytic anemia > Flashcards

Flashcards in Microcytic anemia Deck (18)
1

what does a small RDW (red cell distribution width) mean?

uniform size

2

non heme iron is mostly present in what forms?

sulfate and gluconate

3

iron is best absorbed in what pH environment?

acidic

4

what is the role of hepcidin?

shuts down iron transporter (ferroportin) on duodenal cell, reducing the amount of available iron for circulation

5

which cells produce EPO?

renal fibroblasts

6

where is most of the iron storage in the body located?

circulating RBCs

7

what lab values will you see with iron deficiency anemia?

1. low Hb/Hct
2. low MCV
3. low ferritin (accurate measurement)
4. low transferrin saturation
5. high TIBC
6. reticulocytosis

8

what are the symptoms of IDA?

1. pica / pagophagia
2. restless leg syndrome
3. pallor / pale palmar creases / pale conjunctiva
4. glossitis
5. nail changes

9

what is the key player in anemia of chronic disease?

hepcidin (an acute phase reactant)

10

is anemia of renal disease usually hypochromic, hyperchromic, or normochromic?

normochromic

11

what is the mechanism for anemia of renal disease?

1. renal fibroblasts don't make EPO
2. bone marrow is not stimulated

12

target cells are very common in what conditions?

alpha and beta thalassemia

13

why is there no alpha globin made in B thalassemia?

because you do not have beta subunits - you are producing mostly gamma and delta

14

what are the clinical features of B thalassemia?

1. increased RBC destruction
2. iron overload in RES
3. anemia, hypermetabolic marrow
4. therapeutic phlebotomy
5. transfusion requirement

15

what is the characteristic finding in sideroblastic anemia?

ring sideroblast in the marrow

16

what is the pathogenesis of sideroblastic anemia?

RBCs are not making efficient use of the iron because they are missing a lot of porphyrin rings

17

congenital sideroblastic anemia usually involves what deficiency?

ALA synthase

18

what are pappenheimer bodies?

iron deposits in circulating RBCs