AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Ethyl alcohol Flashcards Preview

Pharmacology > AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Ethyl alcohol > Flashcards

Flashcards in AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Ethyl alcohol Deck (20):
1

Alcohol may cause

- CNS depression
- Vasodilatation
- Hypoglycemia

2

Alcohol

Increases body heat loss

3

True or False. It is undesirable to take alcohol before going outdoors when it extremely cold, but it may be harmless to take some after coming into a warm place from the cold.

TRUE

4

The most common medical complication of alcohol abuse is

- Liver failure including liver cirrhosis
- Tolerance and physical dependence
- Generalized symmetric peripheral nerve injury, ataxia and dementia

5

Effect of moderate consumption of alcohol on plasma lipoproteins is

Raising serum levels of high-density lipoproteins

6

Which metabolic alterations may be associated with chronic alcohol abuse?

Severe loss of potassium and magnesium

7

Alcohol potentiates

- SNS depressants
- Vasodilatators
- Hypoglycemic agents

8

Which drugs is most commonly used for causing a noxious reaction to alcohol by blocking its
metabolism?

Disulfiram

9

Which agents is an inhibitor of aldehyde dehydrogenase?

Disulfiram

10

Indicate the drug, which alters brain responses to alcohol

Naltrexone

11

Which agents is an opioid antagonist?

Naltrexone

12

Alcohol causes an acute increase in the local concentrations of

- Dopamine
- Opioid
- Serotonine

13

Management of alcohol withdrawal syndrome contains

- Restoration of potassium, magnesium and phosphate balance
- Thiamine therapy
- Substituting a long-acting sedative-hypnotic drug for alcohol

14

Indicate the drug, which decreases the craving for alcohol or blunts pleasurable “high” that comes with renewed drinking

Naltrexone

15

The symptoms resulting from the combination of disulfiram and alcohol are

Nausea, vomiting

16

The combination of disulfiram and ethanol leads to accumulation of

Acetaldehyde

17

True or False. The combination of naltrexone and disulfiram should be avoided since both drugs are potential hepatotoxins.

TRUE

18

Indicate the “specific” modality of treatment for severe methanol poisoning

- Dialysis to enhance removal of methanol
- Alkalinization to counteract metabolic acidosis
- Suppression of metabolism by alcohol dehydrogenase to toxic products

19

Which agents may be used as an antidote for ethylene glycol and methanol poisoning?

Fomepizol

20

The principal mechanism of fomepizol action is associated with inhibition of

Alcohol dehydrogenase

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