AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Antidepressant agents

Question 1

The principal mechanism of action of antidepressant agents is

Answer 1

Blocking epinephrine or serotonin reuptake pumps

Question 2

Which agents is related to tricyclic antidepressants?

Answer 2

Amitriptyline

Question 3

Indicate the second-generation heterocyclic drug

Answer 3

Maprotiline

Question 4

Which agents is related to the third-generation heterocyclic antidepressants?

Answer 4

Nefazodone

Question 5

Which antidepressants is a selective serotonin reuptake inhibitor?

Answer 5

Fluoxetine

Question 6

Which antidepressant agents is a selective inhibitor of norepinephrine reuptake?

Answer 6

Maprotiline

Question 7

Indicate the antidepressant, which blocks the reuptake pumps for serotonin and norepinephrine

Answer 7

Amitriptyline

Question 8

Which antidepressants is an unselective MAO blocker and produces extremely long-lasting inhibition of the enzyme?

Answer 8

Tranylcypramine

Question 9

Indicate the irreversible MAO inhibitor, which is a hydrazide derivative

Answer 9

Phenelzine

Question 10

Which MAO inhibitors has amphetamine-like activity and is related to nonhydrazide derivatives

Answer 10

Tranylcypramine

Question 11

Which antidepressants is a selective short-acting MAO-A inhibitor?

Answer 11

Moclobemide

Question 12

Monoamine Oxydase A

Answer 12

Is responsible for norepinephrine, serotonin, and tyramine metabolism

Question 13

Which synapses are involved in depression?

Answer 13

Serotoninergic synapses

Question 14

Block of which type of Monoamine Oxydase might be more selective for depression?

Answer 14

MAO-A

Question 15

The principal mechanism of MAO inhibitor action is

Answer 15

Blocking a major degradative pathway for the amine neurotransmitters, which permits more amines to accumulate in presynaptic stores

Question 16

The irreversible MAO inhibitors have a very high risk of developing

Answer 16

Hypertensive reactions to tyramine ingested in food

Question 17

The most dangerous pharmacodynamic interaction is between MAO inhibitors and

Answer 17

• Selective serotonin reuptake inhibitors
• Tricyclics
• Sympathomimetics

Question 18

Serotonin syndrome is a result of

Answer 18

• Increased stores of monoamine

- Significant accumulation of amine neurotransmitters in the synapses

Question 19

The therapeutic response to antidepressant drugs is usually over a period of

Answer 19

2-3 weeks

Question 20

Which antidepressants may have latency period as short as 48 hours?

Answer 20

Tranylcypromine

Question 21

Which features do MAO inhibitors and tricyclic antidepressants have in common?

Answer 21

Increase levels of biogenic amines

Question 22

Tricyclic antidepressants are

Answer 22

Mixed norepinephrine and serotonin reuptake inhibitors

Question 23

Which autonomic nervous system effects is common for tricyclic antidepressants?

Answer 23

• Antimuscarinic action
• Antihistaminic action
• Alfa adrenoreceptor-blocking action

Question 24

Indicate an effective antidepressant with minimal autonomic toxicity

Answer 24

Fluoxetine

Question 25

Fluoxetine has fewer adverse effects because of

Answer 25

Minimal binding to cholinergic, histaminic, and alfa-adrenergic receptors

Question 26

Which tricyclic and heterocyclic antidepressants has the greatest sedation?

Answer 26

- Doxepin - Amitriptyline - Trazodone

Question 27

Which tricyclic and heterocyclic agents has the least sedation?

Answer 27

Protriptyline

Question 28

Indicate a tricyclic or a heterocyclic antidepressant having greatest antimuscarinic effects

Answer 28

Amitriptyline

Question 29

Indicate a tricyclic or a heterocyclic antidepressant having least antimuscarinic effects

Answer 29

- Trazodone - Buprorion - Mirtazapine

Question 30

Which antidepressants has significant alfa2-adrenoreceptor antagonism?

Answer 30

Mirtazapine

Question 31

Indicate the main claim for an ideal antidepressant agent

Answer 31

- A faster onset of action - Fewer adverse sedative and autonomic effects - Fewer toxicity when overdoses are taken

Question 32

Sedation, peripheral atropine-like toxicity (e.g. Cycloplegia, tachycardia, urinary retention, and constipation), orthostatic hypotension, arrhythmias, weight gain and sexual disturbances are possible adverse effects of

Answer 32

Amitriptyline

Question 33

Which drugs is least likely to be prescribed to patients with prostatic hypertrophy, glaucoma, coronary and cerebrovascular disease?

Answer 33

Amitriptyline

Question 34

Indicate the antidepressant agent, which is a phenyltolylpropylamine derivative

Answer 34

Fluoxetine

Question 35

The mechanism of fluoxetine action includes

Answer 35

- Selective inhibition of serotonine uptake in the CNS - Little effect on central norepinephrine or dopamine function - Minimal binding to cholinergic, histaminic, and alfa-adrenergic receptors

Question 36

Which antidepressants is used for treatment of eating disorders, especially buliemia?

Answer 36

Fluoxetine

Question 37

True or False. Sertaline and paroxetine are similar to fluoxetine in the mechanism of action and therapeutic use, sertaline is less likely to interact adversely with other drugs.

Answer 37

TRUE

Question 38

A highly selective serotonine reuptake inhibitor is

Answer 38

- Sertaline - Paroxetine - Fluoxetine