Antifungals EC Flashcards Preview

Evan's Step 1 Prep Material > Antifungals EC > Flashcards

Flashcards in Antifungals EC Deck (11):
1

Amphotericin B (MOA, Use, Tox)

Binds ERGOSTEROL and forms membrane pores

Serious systemic mycoses
Cryptococcus meningitis (w/ flucytosine)
Blastomyces
Coccidio
Histo
Candida
Mucor

Fever/chills, Hypotension, nephrotoxic, arrhythmias, anemia, IV phlebitis

2

Nystatin (MOA, Use)

Binds ERGOSTEROL and forms membrane pores

Topical "swish and swallow" oral candidiasis
Topical for diaper rash or vaginal candidiasis

3

Azoles (Fluconazole, ketoconazole, clotrimazole, miconazole, itraconazole, voriconazole) (MOA, Use, Tox)

Inhibits P450 conversion of lanosterol to ergosterol

Local and less serious systemic mycoses

Testosterone synthesis inhibition (gnyecomastia), liver dysfunction

4

Flucytosine (MOA, Use, Tox)

Inhibits CYTOSINE DEAMINASE conversion of 5-fluorouracil

Systemic fungal infections in combination with amphotericin B

Bone marrow suppression

5

Caspofungin, Micafungin (MOA, Use, Tox)

Inhibit BETA GLUCAN and therefore fungal cell wall synthesis

Invasive aspergillosis
Candida

Fluishing

6

Terbinafine (MOA, Use, Tox)

Inhibits SQUALENE EPOXIDASE

Treats dermatophytoses (esp fingers and toe fungal infections)

Abnormal liver function, Visual disturbances

7

Griseofulvin (MOA, Use, Tox)

Interferes with microtubule function; disrupts mitosis.

Oral treatment of superficial fungal infections

Teratogenic, carcinogenic, confusion, headaches, increases P450s and warfarin metabolism

8

Chloroquine (MOA, Use, Tox)

Blocks detoxification of Heme into HEMOZOIN (heme accumulates and is toxic to plasmodia)

Treatment of malaria other than P. falciparum

Retinopathy

9

Treatment of P. falciparum

Atovaquone/proguanil

10

Antiprotozoan therapy

Pyrimethamine (toxo)
Suramin and melarsoprol (T. brucei)
Nifurtimox (T. cruzi)
Sodium stibogluconate (leishmaniasis)

11

Antihelminthic theraphy

Mebendazole
Pyrantel pamoate
Ivermectin
Diethylcarbamazine
Praziquantel (esp Schistosoma)

Immobilize helminths

Decks in Evan's Step 1 Prep Material Class (72):