Antivirals EC Flashcards Preview

Evan's Step 1 Prep Material > Antivirals EC > Flashcards

Flashcards in Antivirals EC Deck (15):
1

Zanamivir, Oseltamivir (MOA, Use, Tox)

Inhibit influenza NEURAMINIDASE and block release of progeny

Treats influenza A and B

2

Ribavirin (MOA, Use, Tox)

Inhibits IMP DEHYDROGENASE and therefore guanine nucleotide synthesis

RSV, Chronic hep. B

Hemolytic anemia, Teratogenic

3

Acyclovir (MOA, Use, Tox)

Inhibits VIRAL DNA POLYMERASE
Monophosphated by thymidine kinase - Guanosine analog

Treat HSV and VZV

4

Ganciclovir (MOA, Use, Tox)

Inhibits VIRAL DNA POLYMERASE
5'-monophosphate formed by thymidine kinase- Guanoside analog

Treat CMV

Leukopenia, Neutropenia, Thrombocytopenia
Renal toxicity

5

Foscarnet (MOA, Use, Tox)

Inhibits VIRAL DNA POLYMERASE
Binds to PYROPHOSPHATE BINDING SITE
"FOScarnet=pyroFOSphate analog"

Acyclovir resistant HSV
Failure of gancyclovir in CMV retinitis

Nephrotoxic

6

Cidofovir (MOA, Use, Tox)

Inhibits VIRAL DNA POLYMERASE

CMV retinitis
Acyclovir resistant HSV

7

What does HAART therapy consist of?

3 drugs to prevent resistance:

2 NRTIs (nucleoside reverse transcriptase inhibitors)
+
1 Protease inhibitor
or
1 NNRTI (non-nucleoside reverse transcriptase inhibitor)
or
1 Integrase inhibitor

8

Lopinavir, Atazanavir, Darunavir, Fosamprenavir, Saquinavir, Ritonavir, Indinavir (MOA, Use, Tox)

HIV PROTEASE INHIBITORS prevent maturation of new virus

"NAVIR tease a PROTEASE"

Hyperglycemia
GI
Lipodystrophy
Nephropathy
Hematuria (Indinavir)

9

Why is Ritonavir often given?

To BOOST concentrations of other drugs by inhibiting P450s

10

Tenofovir, Emtricitabine, Abacavir, Lamivudine, Zidovudine, Didanosine, Stavudine (MOA, Use, Tox)

NRTIs (Nucleoside reverse transcriptase inhibitors)

Competitively inhibit HIV reverse transcriptase
Chain termination (lack 3'OH)

Bone marrow suppression (reversible)
Peripheral neuropathy
Lactic acidosis
Anemia (Zidovudine)

11

What NRTI does not have to be activated?

Tenofovir is a nucleotide analog and does not have to be activated

All other NRTIs must be phosphorylated to be active

12

What NRTI is used for prophylaxis in pregnancy with a HIV+ woman?

Zidovudine

13

Nevirapine, Efavirenz, Delavirdine (MOA, Use, Tox)

Bind reverse transcriptase at a different spot

Do not need to be activated

Bone marrow suppression (reversible)
Peripheral neuropathy
Rash

14

Raltegravir (MOA, Use, Tox)

Inhibits HIV integrase (integration into genome)

Hypercholesterolemia

15

Interferons (MOA, Use, Tox)

Glycoproteins synthesized by virus infected cells; block viral replication

IFN-alpha: Hep. B and C, Kaposi's sarcoma
IFN-beta: MS
IFN-gamma: NADPH oxidase deficiency

Neutropenia
Myopathy

Decks in Evan's Step 1 Prep Material Class (72):