Chemotherapeutic Agents EC Flashcards Preview

Evan's Step 1 Prep Material > Chemotherapeutic Agents EC > Flashcards

Flashcards in Chemotherapeutic Agents EC Deck (34):
1

What drugs act on the S phase of the cell cycle?

Etoposide
Antimetabolites (MTX, 5FU, Cytarabine, Azathioprine, 6-MP, 6-TG)

2

What drugs act on phase G2 of the cell cycle?

Etoposide
Bleomycin

3

What drugs act on the M phase of the cell cycle?

Vinca alkaloids (inhibit microtubule formation)
Taxols (ie. paclitaxel - inhibit microtubule disassembly)

4

Methotrexate (MOA, Use, Tox)

Folic acid analog (inhibits DIHYDROFOLATE REDUCTASE)
(decreased dTMP, decreased DNA synthesis)

Leukemias, Lymphomas, Choriocarcinoma, Sarcoma
Abortion, Ectopic pregnancy, RA, Psoriasis

Myelosuppression (reversible with leucovorin)
Fatty change in liver
Mucositis
Teratogenic

5

5-Fluorouracil (MOA, Use, Tox)

Pyrimidine analog (inhibits THYMIDYLATE SYNTHASE)
(decerase dTMP, decreased DNA synthesis)

Colon cancer, Basal cell carcinoma

Myelosuppression (not reversible)
Photosensitivity

6

Cytarabine (MOA, Use, Tox)

Pyrimidine analog (inhibits DNA POLYMERASE)

Leukemias, Lymphomas

Leukopenia, Thrombocytopenia, megaloblastic anemia

7

Azathioprine, 6MP, 6TG (MOA, Use, Tox)

Purine analog (decrease de novo synthesis)

Leukemias

Bone marrow, GI, liver
Met. by xanthine oxidase (toxic with allopurinol-xanthine oxidase inhibitor )

8

Dactinomycin [actinomycin D] (MOA, Use, Tox)

Antitumor antibiotic
Intercalates in DNA

Wilm's tumor, Ewing's sarcoma, rhabdomyosarcoma,
Used for childhood tumors
"Children ACT out"

9

Doxorubicin [Adriamycin] (MOA, Use, Tox)

Antitumor antibiotic
Generate free radicals
Intercalates in DNA

Solid tumors, Leukemias, Lymphomas

Dilated cardiomyopathy, Myelosuppression, Alopecia,
Dexrazoxane (Fe chelator) prevents cardiotoxicity

10

Bleomycin (MOA, Use, Tox)

Antitumor antibiotic
Generates free radicals

Testicular cancer
Hodgkin's lymphoma

Pulmonary fibrosis, Skin changes

11

Cyclophosphamide (MOA, Use, Tox)

Alkylating agent
Covalently X-link DNA at guanine N-7

Solid tumors, Leukemia, Lymphoma, some brain cancers

Myelosuppression
Hemorrhagic cystitis (prevented with Mesna-binds Acrolein)

12

Nitrosoureas [-mustine] (MOA, Use, Tox)

Alkylating agent
(requires bioactivation)

Brain tumors (crosses BBB)

CNS toxicity

13

Busulfan (MOA, Use, Tox)

Alkylating agent

CML, bone marrow ablation prior to transplantation

Pulmonary fibrosis
Hyperpigmentation

14

Vincristine/Vinblastine (MOA, Use, Tox)

Bind tubulin and block formation of mitotic spindle

Solid tumors, Leukemias, Lymphomas

Vincristine- Neurotoxicity and paralytic ileus
VinBLASTine-BLASTS Bone marrow

15

Paclitaxel (MOA, Use, Tox)

Hyperpolymerize microtubules (inhibit microtubule breakdown)

Ovarian and breast carcinomas

Myelosuppression and hypersensitivity

16

Cisplatin/Carboplatin (MOA, Use, Tox)

Cross-link DNA

Testicular, bladder, ovary, and lung carcinomas

Nephrotoxicity and acoustic nerve damage
(prevent nephrotox. w/ Amifostine (free radical scavenger)

17

Etoposide (MOA, Use, Tox)

Inhibit topoisomerase II (DNA degradation)

Solid tumors, leukemias, lymphomas

Myelosuppression, GI irritation, Alopecia

18

Hydroxyurea (MOA, Use, Tox)

Inhibits RIBONUCLEOTIDE REDUCTASE (decrease DNA synthesis)

Melanoma, CML, sickle cell disease (increases HbF)

Bone marrow suppression, GI upset

19

Prednisone/Prednisolone (MOA, Use, Tox)

May trigger apoptosis (even in undividing cells)

CLL, non-Hodgkin's lymphomas, (immunosuppressant)

Cushing-like, immunosuppression, cataracts, acne, hypertension, peptic ulcers, hyperglycemia, phychosis

20

Tamoxifen/Raloxifene (MOA, Use, Tox)

SERMs (antagonist in breast, agonist in bone)

Breast cancer treatment and prevention, Prevent osteoporosis

Tamoxifen-increase risk of endometrial cancer, hot flashes

21

Trastuzumab (MOA, Use, Tox)

HER-2 (TK) MAB

HER-2 + breast cancer

Cardiotoxicity

22

Imatinib (MOA, Use, Tox)

Philidelphia chromosome bcr-abl TK inhibitor

CML, GI stromal tumors

Fluid retention

23

Rituximab (MOA, Use, Tox)

MAB against CD20 (B-cells)

non-Hodgkin's, RA (w/ MTX)

24

Vemurafenib (MOA, Use, Tox)

Small molecule inhibitor of forms of the B-Raf kinase with the V600E mutation

Metastatic melanoma

25

Bevacizumab (MOA, Use, Tox)

MAB against VEGF (inhibits angiogenesis)

Solid tumors

26

Cisplatin/Carboplatin classic toxicity

Acoustic nerve damage
Nephrotoxicity

27

Vincristine classic toxicity

Peripheral neuropathy

28

Bleomycin/Busulfan classic toxicity

Pulmonary fibrosis

29

Doxorubicin classic toxicity

Cardiotoxicity

30

Trastuzumab classic toxicity

Cardiotoxicity

31

Cyclophosphamide classic toxicity

Hemorrhagic cystitis

32

5-FU classic toxicity

Myelosuppression

33

6-MP classic toxicity

Myelosuppression

34

Methotrexate classic toxicity

Myelosuppression

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