Glomerular Diseases EC Flashcards Preview

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Flashcards in Glomerular Diseases EC Deck (14):

Proteinuria (>3.5g/day), Hyperlipidemia, fatty casts in urine, and edema.

Nephrotic syndrome

Associated with thromboembolism (ATIII loss)
Increased risk of infections


Segmental sclerosis and hyalinosis on LM
Effacement of foot processes on EM
Associated with HIV

Focal segmental glomerulosclerosis

Most common cause of nephrotic syndrome in adults


Diffuse capillary and GBM thickening on LM
"Spike and dome" appearance with subepithelial deposits on EM
Granular appearance on IF

Membranous nephropathy

Idiopathic, drugs, infections, SLE) (granular appearance on IF, and solid tumors


Normal glomeruli on LM
Foot process effacement on EM
Selective loss of albumin, not globulins

Minimal change disease

May be triggered by a recent infection or immune stimulus
Most common in CHILDREN
responds to corticosteroids


Congo red stain shows apple-green birefringence under polarized light
Associated with multiple myeloma, TB, RA



Subendothelial IC deposits with granular IF
"tram-track" appearance due to GMB splitting caused by mesangial growth

Type I Membranoproliferative Glomerulonephritis

Associated with HBV and HCV


Intramembranous IC deposits: "dense deposits"

Type II Membranoproliferative Glomerulonephritis

Associated with C3 and nephritic factor


Nonenzymatic glycosylation of GBM (increased permeability and thickening)
NEG of efferent arterioles (Increased GFR, mesangial expansion)
Eosinophilic nodular glomerulosclerosis (Kimmelstiel-Wilson lesions)

Diabetic Glomerulonephropathy


Hematuria, RBC casts in urine. Associated with azotemia, oliguria, hypertension, and proteinuria (<3.5g/day)

Nephritic syndrome = Inflammation


Glomeruli enlarged and hypercellular, neutrophils, "lumpy-bumpy" appearance on LM
Subepithelial immune complex humps on EM
Granular appearance due to IgG, IgM, and C3 deposits along GMB and mesangium on IF
Peripheral and periorbital edema, dark urine, hypertension

Acute Poststreptococcal Glomerulonephritis

Most often in children


Crescent-moon shape consisting of fibrin and C3b with glomerular parietal cells, monocytes, and macrophages

Rapidly progressive glomerulonephritis

Goodpasture's = type II hypersensitivity, antibodies to GBM and alveolar basement membrane. LINEAR IF and hemoptysis/hematuria

Granulomatosis with polyangitis (c-ANCA)

Microscopic polyangitis (p-ANCA)


"Wire looping" of capillaries
Subendothelial IgG-based immune complexes with C3
Granular upon IF

Diffuse proliferative glomerulonephritis

Due to SLE (most common cause of death) or MPGN


Henoch-Schonlein purpura
Mesangial proliferation on LM
Mesangial IC deposits on EM
IgA based IC deposits in mesangium on IF

Berger's Disease (IgA nephropathy)

Often presents with a UTI or gastroenteritis


Mutation in type IV collagen
Split basement membrane
Glomerulonephritis, deafness, and eye problems

Alport syndrome

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