Respiratory Pharm EC Flashcards Preview

Evan's Step 1 Prep Material > Respiratory Pharm EC > Flashcards

Flashcards in Respiratory Pharm EC Deck (17):
1

Diphenhydramine, Dimenhydrinate, Chlorpheniramine (MOA, Use, Tox)

First generation H1 Blockers

Used in allergy, motion sickness, sleep aid

Tox=Sedation, antimuscarinic, anti-alpha-adrenergic

2

Loratadine, Fexofenadine, Desloratadine (MOA, Use, Tox)

Second generation H1 Blocker

Used in allergy

Far less sedating (does not enter CNS)

3

Albuterol (MOA, Use)

Beta-2 agonist (relaxes bronchial smooth muscle)

Used during acute asthma exacerbation

4

Salmeterol, Formoterol (MOA, Use, Tox)

Beta-2 agonists (long acting)

Used for prophylaxis of asthma

Can cause tremor and arrhythmia

5

Theophylline (MOA, Use, Tox)

Methylxanthine (INHIBIT PDE)

Used to in asthma

Narrow TI: causes cardiotoxicity and neurotoxicity
metabolized by p450
blocks actions of adenosine

6

Ipratropium (MOA, Use)

Muscarinic antagonist (prevent bronchoconstriction)

Used in Asthma, COPD

7

Beclomethasone, Fluticasone (MOA, Use)

Corticosteroids
(inhibit cytokine synthesis by inactivating NF-kB which is the transcription factor that induces production of TNF-alpha)

First line for chronic asthma

8

Montelukast, Zafirlukast (MOA, Use)

Block Leukotriene receptors

Especially useful in aspirin-induced asthma (COX inhibitors cause shunting down 5-lipoxygenase/Leukotriene pathway)

9

Zileuton (MOA, Use)

5-Lipoxygenase Inhibitor (blocks conversion of arachidonic acid to leukotrienes)

Used in asthma

10

Omalizumab (MOA, Use)

Monoclonal antibody to IgE

Used in allergic asthma resistant to other treatment

11

Guaifenesin (Use)

Expectorant - thins respiratory secretions

Does not suppress cough reflex

12

N-acetylcysteine (Use)

Expectorant

Loosens mucus plugs in CF patients

Antidote for acetaminophen OD (replenishes glutathione)

13

Cromolyn Sodium (MOA, Use)

Stabilizes mast cells - inhibiting histamine release

Used in sports induced asthma - must be taken before exposure

14

Bosentan (MOA, Use)

Endothelin-1 Receptor Antagonist (decreasing pulmonary vascular resistance)

Used to treat pulmonary arterial hypertension

15

Dextromethorphan (MOA, Use)

NMDA-glutamate receptor Antagonist
Synthetic codeine analog (mild opioid)

Used as antitussive

16

Pseudoephedrine, Phenylephrine (MOA, Use, Tox)

Alpha-agonists (nasal decongestants)

Reduce hyperemia, edema, and nasal congestion
Open obstructed eustachian tubes
Pseudoephedrine also used as a stimulant

Can cause hypertension
Pseudoephedrine can also cause anxiety

17

Methacholine (MOA, Use)

Muscarinic Receptor Agonist

Used in asthma challenge testing

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