Antimycobrials

Question 1

___ inhibits mycolic acid synthesis

Answer 1

isoniazid

Question 2

most important drug used in treatment of TB

Answer 2

isoniazide

Question 3

causes neurotoxicity

Answer 3

isoniazid

Question 4

___ structural congener of pyridoxine

Answer 4

isoniazied

Question 5

Isoniazid has a high level of resistance due to a deletion of this gene

Answer 5

KatG gene

Question 6

What enzyme is involved in bioactivation in INH

Answer 6

catalase-peroxidase enzyme

Question 7

Low level resistance to isoniazid is due to a deletion of what gene>

Answer 7

inhA gene

Question 8

inhA gene targets what enzyme

Answer 8

acyl protein reductase

Question 9

___ inhibits DNA-dependent RNA polymerase

Answer 9

rifampicin

Question 10

cause red orang ebody fluids

Answer 10

rifampicin

Question 11

also used for atypical mycobacterial infections

Answer 11

rifampicin

Question 12

a rifampin derivative used to prevent hepatic encephalopathy

Answer 12

rifaximin

Question 13

___ is the preferred TB drug for AIDS patient

Answer 13

rifampicin

Question 14

resistance pattern of rifampicin

Answer 14

changes in drug sensitivity of the polymerase enzyme

Question 15

bactericidal to actively dividing mycobacteria

Answer 15

Pyrazinamide

Question 16

most hepatotoxic anti TB drug

Answer 16

pyrazinamide

Question 17

___ is also known as sterilizing agent used in the first 2 months

Answer 17

pyrazinamide

Question 18

resistance pattern of pyrazinamide is via mutation in what gene

Answer 18

pncA

Question 19

what are the resistance pattern of pyrazinamide?

Answer 19

1. mutation in pncA

2. Efflux systems

Question 20

___ Inhibits arabinosy transferase

Answer 20

ethambutol

Question 21

arabinosyl transferase is involved in the sysnthesis of what component in mycobacterial cell wall

Answer 21

arabinogalactan

Question 22

resistance to ethambutol is due to

Answer 22

mutation in emb gene

Question 23

___ binds to S12 ribosomal subunit

Answer 23

Streptomycin (an aminoglycoside)

Question 24

____ has no cross-resistance with INH

Answer 24

Ethionamide

Question 25

[leprosy drug] inhibits folic acid synthesis

Answer 25

dapsone

Question 26

[leprosy drug] back up drug for PCP pneumonia

Answer 26

dapsone

Question 27

___ is a repository form of dapsone which has drug action that can last for several months

Answer 27

acedapsone

Question 28

[leprosy drug] binds to guanine bases in bacterial DNA

Answer 28

clofazimine

Question 29

[leprosy drug] cause skin discoloration

Answer 29

clofazimine

Question 30

What is the mycobacterial prophylaxis for patients with CD4 count less than 50

Answer 30

1. Clarithromycin 2. Azithromycin 3. with or without Rifabutin

Question 31

What is the treatment for atypical mycobacterial infection?

Answer 31

1. Azithromycin OR clarithromycin 2. Ethambutol 3. Rifabutin