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Infectious Disease (OSI type) > Antiviral > Flashcards

Antiviral Flashcards

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1
Q

Antiviral drugs that block viral entry

A
  1. Enfuvi
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2
Q

Most hematotoxic anti-HIV drug

A

Zidovudine

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3
Q

[HIV Antiviral]

Associated with pancreatitis NRTI

A

Didinosine

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4
Q

[HIV Antiviral]

Least hematotoxic NRTI

A

zalcitibine

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5
Q

[HIV Antiviral]

least potent NRTI

A

Lamivudine

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6
Q

[HIV Antiviral]

long half life, OK for pregnant NRTI

A

Emtricitabine

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7
Q

[HIV Antiviral]

Associated with hypersensitivity NRTI

A

Abacavir

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8
Q

[HIV Antiviral: NNRTI]

Associated with nightmares

A

Efivarenz

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9
Q

[HIV Antiviral: Protease inhibitors]

No insulin resistance

A

Atazanavir

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10
Q

Drugs for herpes

A
  1. Foscarnet
  2. Acyclovir
  3. Ganciclovir
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11
Q

Drugs for influenza

A
  1. Amantadine

2. Zanamivir

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12
Q

Drugs for HepB and HepC

A
  1. Lamivudine
  2. Ribavirin
  3. Boceprevir
  4. Sofosbuvir
  5. Interferon alpha
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13
Q

What are the steps in viral replication

A
  1. Attachment
  2. Penetration
  3. Uncoating
  4. Synthesis, nucleic acid
  5. Synthesis protein
  6. PACKaging
  7. release
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14
Q

What is the MOA of antiherpes drug?

A

inhibit viral DNA polymerase,

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15
Q

what activates acyclovir

A

viral thymidine kinase

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16
Q

[Drugs for herpes]

inhibits fusion between HSV envelope and plasma membrane

A

Docosanol

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17
Q

[Drugs for herpes]

flourinated pyrimidine nucleoside

A

Trifluridine

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18
Q

[Drugs for herpes]

inhibit the viral DNA polymerase of shingles and EBV

A

valomaciclovir

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19
Q

[Drugs for herpes]

prodrug of acyclovir

A

Valcyclovir

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20
Q

[Drugs for herpes]

does not cause chain termination

A

penciclovir

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21
Q

[Drugs for herpes]

prodrug converted to penciclovir

A

famciclovir

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22
Q

[Drugs for herpes]

that cause bone marrow suppresion

A

Ganciclovir

Valgancyclovir

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23
Q

CMV resistance to ganciclovir is due to?

A

mutation in viral DNA polymerase

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24
Q

___ given as intraocular implant for CMV retinitis

A

Ganciclovir

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25
Drugs for CMV
1. Ganciclovir 2. Valganciclovir 3. Cidofovir
26
Antiviral which can be given in cases of acyclovir- ajnd ganciclovir-resistance
Cidofovir
27
An antiviral that is a pyrophosphate analog
Foscarnet
28
What will you give to HSV strains with no thymidine kinase activity?
Foscarnet
29
What are the components of your HAART?
2 NRTI | 1 PI
30
What are examples of your NRTI
1. Abacavir 2. Didanosine 3. Emtricitabine 4. Lamivudine 5. Stavudine 6. Tenofovir 7. Zalcitabine, Zidovudine
31
[NRTI] DOC to prevent maternal-fetal HIV transmission
Safe for pregnancy 1. Abacavir 2. Emtricitabine 3. Lamivudine 4. Tenofovir
32
What differentiates NRTI and NNRTI
1. NRTI - phosphorylation needed | 2. NNRTI - no phosphorylation needed
33
What are examples of your NNRTI
1. Nevirapine 2. Efavirenz 3. Etravirine 5. Delavirdine 6. Rilpivirine
34
Cite examples of you protease inhibitors
all that ends in 'NAVIR"
35
Protease inhibitor that cause peripheral neuropathy
Atazanavir
36
Protease inhibitor that cause hyperbilirubinemia and nephrolithiasis
Indinavir
37
___ binds to gp41 subunit
Enfuvirtide (prevents fusion)
38
____ CCR5 receptor antagonist
Maraviroc
39
___ integrase inhibitor leading to inhibition of strand transfer
rategravir
40
[Drugs for influenza] inhibit early step replication, prevents uncoating
Amantadine
41
[Drugs for influenza] cause livedo reticularis
Amantadine | Rimandatine
42
[Drugs for influenza] used to treat parkinsonism
amantadine
43
[Drugs for influenza] inhibits neuraminidase
Oseltamivir
44
Enzyme used to release progeny virus in influenza
neuraminase
45
[Drugs for influenza] Causes bronchospasm in asthmatics
Zanamivir
46
What is the drug of choice for influenza
Oseltamivir
47
DOC for H1N1
Oseltamivir
48
[HepB and HepC drugs] what are the contraindications to using interferon alpha for HBV and HCV
1. Autoimmune disease 2. history of cardiac arrhythmias 3. Pregnancy
49
[HepB drug] inhibits HBV DNA polymerase
1. Lamivudine 2. Adefovir 3. Dipivoxil 4. Entecavir 5. Telbivudine 6. Tenofovir 7. Clevudine
50
Drugs used both in hepB and HIV
Lamivudine
51
[HepB drug] causes lactic acidosis, renal and hepatic toxicity
Lamivudine
52
HBV and HIV coinfection increases the risk of what of lamivudine is used
pancreatitis
53
___ inhibit guanosine triphosphate formation
Ribavirin
54
antiviral drugsused for RSV
Ribavirin
55
Drug for RSV that uses a monoclonal antibody agains RSV antigen
Pavilizumab
56
immune response modifier effective for external genital and perianal warts
Imiquimod
57
used to treat subacute sclerosing panencephalitis
Inosine acedoben dimerpranol
58
___ a prodrug that become active uridine analog triphosphate. Used to treat HCV
Sofosbuvir
59
[HIV Drug] NRTI given if creatinine clearance is <60
Abacavir
60
[HIV Drug] used for patients 12 years old and above, CD4 >350, non pregnant, not on rifampicin containing regimen
Rilpinavir
61
[HIV Drug] Adolescent >/10 years old
2NRTI + 1 NNRTI Tenofovir + Lamivudine + Efavirenz
62
[HIV Drug] Children 3 to less than 10 years old
2 NRTI + 1 NNRTI Abacavir + Lamivudine + Efavirenz
63
[HIV Drug] Neonates with Hct <40%
Abacavir over Zidovudine
64
[HIV Drug] 0-2 weeks old
Zidovudine + Lamivudine + Nevirapine
65
[HIV Drug] 2 weeks to 3 months old
Abacavir

Infectious Disease (OSI type) (24 decks)

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