Antiprotozoal

Question 1

[Drugs for Amebiasis]

Tissue amebicide

Answer 1

1. Chloroquine
2. Emetines
3. Metronidazole
4. Tinidazole

Question 2

[Drugs for Amebiasis]

Luminal amebicide

Answer 2

1. Paromomycin
2. Iodoquinol
3. Diloxanide furoate

Question 3

[Drugs for Amebiasis]

Asymptomatic, intestinal indection

Answer 3

1. Diloxanide furoate

Question 4

[Drugs for Amebiasis]

Mild to moderate intestinal infection

Answer 4

1. Metronidazole PLUS

2. luminal agent

Question 5

[Drugs for Amebiasis]

Severe intestinal infection

Answer 5

1. Metronidazole OR tinidazole PLUS

2. Luminal agent

Question 6

[Drugs for Amebiasis]

Hepatic abscess and other extraintestinal disease

Answer 6

1. Metronidazole OR tinidazole

2. Luminal agent

Question 7

[Drugs for Amebiasis]

___ inhibits protein synthesis, Blocks ribosomal movement.

Answer 7

Emetine

Back up drug only

Question 8

[Drugs for Amebiasis]

SE: Thyroid enlargement, peripheral neuropathy, visual dysfunction

Answer 8

Iodoquinol

Question 9

[Drugs for Amebiasis]

Reactive reduction by ferredoxin forming free radicals that disrupt ETC

Answer 9

Metronidazole

Question 10

[Drugs for Amebiasis]

causes dark urine, leukopenia, dizziness, disulfram reaction

Answer 10

Metronidazole

Question 11

[Drugs for Amebiasis]

used to treat asymptomatic cyst carriers

Answer 11

paromomycin

Question 12

[Drugs for Amebiasis]

used to treat metronidazole-resistant amebiasis

Answer 12

nitazoxanide

Question 13

[Drugs for pneumocytosis and toxoplansmosis]

___ blocks dihydropteroate synthase and dihydrofolate reductase

Answer 13

Co-trimoxazole

Question 14

[Drugs for pneumocytosis and toxoplansmosis]

prophylaxis treatment for Pneumocytosis

Answer 14

Co-trimoxazole

Question 15

[Drugs for pneumocytosis and toxoplansmosis]

prophylaxis for T. gondii and I. bello

Answer 15

Co-trimoxazole

Question 16

[Drugs for pneumocytosis and toxoplansmosis]

Inhibits glycolysis or interferes with nucleic acid metabilis; back up treatment of pneumocystosis

Answer 16

pentamidine

Question 17

[Drugs for pneumocytosis and toxoplansmosis]

can be used to treat trypanosomiasis administered via nasal spray

Answer 17

pentamidine

Question 18

What is the DOC for prophylaxis and treatment of Toxoplasmosis?

Answer 18

1. Sulfadiazine-Pyrimethamine OR

2. Sulfadiazine- Clindamycin

Question 19

[Trypanosomiasis: Sleeping Sickness]

DOC for Early, west african

Answer 19

Pentamidine

Question 20

[Trypanosomiasis: Sleeping Sickness]

DOC for West african, wtih CNS involvement

Answer 20

Eflornithine

Question 21

[Trypanosomiasis: Sleeping Sickness]

DOC for Early, east african

Answer 21

Suramin

Question 22

[Trypanosomiasis: Sleeping Sickness]

DOC for east african, with CNS involvement

Answer 22

Melarsoprol

Question 23

DOC for african sleeping sickness, hemolypmhatic stage

Answer 23

Pentamidine

Question 24

DOC for Kala-azar prophylaxis

Answer 24

Pentamidine

Question 25

Back up drug for onchocerciasis

Answer 25

Suramin

Question 26

[Trypanosomiasis: Sleeping Sickness] ___ is a suicide inhibitor of ornithine decarboxylase

Answer 26

Eflornithine Can cross BBB

Question 27

[Trypanosomiasis: Sleeping Sickness] ___is an organic arsenical. Inhibits enzyme sulfhydryl groups in trypanosomes

Answer 27

Melarsoprol can cross BBB

Question 28

[Trypanosomiasis: Sleeping Sickness] inhibit trypanothione reductase

Answer 28

nifurtimox Back up drug for african sleeping sickness

Question 29

DOC for Chagas Disease

Answer 29

Nifurtimox

Question 30

What is the DOC for leishmaniasis except in india

Answer 30

Sodium stibogluconate

Question 31

What are the alternative drug for Kala-azar?

Answer 31

1. Pentamidine | 2. Miltefosine

Question 32

What are the alternative drug for cutaneous leishmaniasis?

Answer 32

1. Fluconazole | 2. Metronidazole

Question 33

What are the alternative drug for mucocutaneous leishmaniasis?

Answer 33

1. Amphotericin B

Question 34

DOC for Babesia

Answer 34

1. Clindamycin or Quinine

Question 35

DOC for Balantidium coli

Answer 35

1. Tetracycline

Question 36

DOC for Cryptosporodium sp

Answer 36

1. Paromomycon

Question 37

DOX for T. gondii

Answer 37

1. Pyrimethamine + Cindamycin

Question 38

DOC for T. cruzi

Answer 38

1. Nifurtimox

Question 39

DOX for T. gondii

Answer 39

1. Pyrimethamine + Cindamycin

Question 40

DOC for T. cruzi

Answer 40

1. Nifurtimox