Antimalarials

Question 1

Can cause dose dependent toxicity

BOV, dizziness, flushed skin, sweaty skin, nausea, vomiting, tinnitus

Answer 1

Quinidine

Question 2

Cite examples of tissue schizonticides

Answer 2

1. Primaquine

2. Atovaquone

Question 3

Cite examples of bloodschizonticides

Answer 3

1. Chloroquine
2. Quinine
3. Mefloquine
4. Atovaquone
5. Pryimethamine
6. Artemisinin
7. Halofantrine
8. Artemisinin

Question 4

Cite examples of gametocides

Answer 4

1. Primaquine

Question 5

Cite examples of sporonticides

Answer 5

1. Proguanil

2. Pyrimethamine

Question 6

___ is a blood schizontocide that prevents polymerization of heme into hemozoin;

also given to amebic liver abscess and RA

Answer 6

chloroquine

Question 7

___ is a blood schizontocide that may cause auditory impairment, psychosis, QT prolongation, precipitate porphyria

Answer 7

Chloroquine

Question 8

___ is a blood schizontocide that complexes with DNA to prevent strand separation

Answer 8

Quinine

Question 9

SE: headache, tinnitus, vertigo

Answer 9

Quinine

This is a case of cinchonism

Question 10

Can cause blackwater fever

Answer 10

quinine

Question 11

DOC for malaria in pregnant patient

Answer 11

Quinine

Question 12

To limit the toxicity of quinine, you should give

Answer 12

1. Doxycycline or

2. Clindamycin

Question 13

___ is a blood schizontocide. another alternative to quinine in acute attacks of falciparum

Answer 13

Mefloquine

Question 14

___ is a blood schizontocide wherein the SE is psychosis

Answer 14

Mefloquine

Question 15

___ is a blood gametocide that forms electron-transferring redox compounds that act as cellular oxidants

Answer 15

Primaquine

Question 16

___ is a blood gametocide that is the radical cure for P. vivax and P. ovale

Answer 16

Primaquine

Question 17

___ is a blood gametocide that is the termina cure for P. vivax and P. ovale

Answer 17

Primaquine

Question 18

___ is a blood gametocide that is used to treat PCP pneumonia

Answer 18

Primaquine

Question 19

___ is a blood gametocide that is used to kill hypnozoites

Answer 19

Primaquine

Question 20

In atovaquone-proguanil combination, which is a blood and tissue schizontocide?

Answer 20

Atovaquone

• disrupt ETC

Question 21

In atovaquone-proguanil combination, which is a sporonticide?

Answer 21

Proguanil

• inhibits folate synthesis

Question 22

___ is used to treat chlorquine resistant P. falciparum in all its stages

Answer 22

Atovaquone-Proguanil

Question 23

____ is an blood schizonticide that sequentially blocks folic acid synthesis.

Answer 23

Sulfadoxine-Pyrimethamine

Question 24

___ chemoprophylaxis for multidrug resistant malaria; also a tetracycline

Answer 24

Doxycycline

Question 25

Common side effect of doxycycline is headache without organic lesion. also called

Answer 25

pseudotumor cerebri

Question 26

Used in combination with artemether to treat chloroquine reistant malaria, and severe falciparum malaria

Answer 26

Lumfantrine

Question 27

___ is a blood schizontozide that forms toxic free radicals in malarial food vacuole.

Answer 27

Artemisinin

Question 28

What is the DOC for uncomplicated falciparum malaria in the philippines

Answer 28

Artemether-Lumefantrine (Co-Artem) not safe during the first trimester

Question 29

What is the DOC for P. vivax and P. ovale

Answer 29

1. Chloroquine then | 2 Primaquine

Question 30

What is the DOC for severe P. falcoparum

Answer 30

1. Artesunate then Doxycycline OR | 1. Clinamycin or Co-arten

Question 31

[Malaria prophylaxis] In chlorquine-sensitive areas

Answer 31

Chlorquine 500mg/tab 1 tab weekly

Question 32

[Malaria prophylaxis] In chlorquine-resistant areas

Answer 32

1. Mefloquine 250mg/tab 1 tab weekly | 2. Malarone (Atovaquone250/Proguanil 100)/tab 1 tab OD

Question 33

[Malaria prophylaxis] In multidrug resistant areas

Answer 33

1. Doxycycline 100mg/tab 1 tab OD

Question 34

[Malaria prophylaxis] for P. vivax and P. ovale

Answer 34

1. Primaquine 30mg OD x 2 weeks

Question 35

An immunomodulatory agent used to treat malaria

Answer 35

mepacrine