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Flashcards in Antipsychotic Drugs & Lithium Deck (38):
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Phenothiazines

Chlorpromazine
Fluphenazine
Thioridazine

1

Chlorpromazine

Phenothiazine

2

Fluphenazine

Phenothiazine

3

Thioridazine

Phenothiazine

4

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Mechanism of action

Blockade of D2 receptors >> 5-HT2A receptors

5

Blockade of D2 receptors >> 5-HT2A receptors

Chlorpromazine, Fluphenazine, Thioridazine, (Phenothiazines)
Thiothixene, (Thioxanthene)
Haloperidol, (Butyrophenone)

Mechanism of action

6

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Effects

a-Receptor blockade
Muscarinic (M)-receptor blockade
H1-receptor blockade
CNS depression (sedation)
Decreased seizure threshold
QT prolongation

7

a-Receptor blockade
Muscarinic (M)-receptor blockade
H1-receptor blockade
CNS depression (sedation)
Decreased seizure threshold
QT prolongation

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)
Thiothixene
Effects

8

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)
Thiothixene
Clinical applications

PSYCHIATRIC: schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase) NONPSYCHIATRIC: antiemesis, preoperative sedation (promethazine), pruritus

9

PSYCHIATRIC: schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase) NONPSYCHIATRIC: antiemesis, preoperative sedation (promethazine), pruritus

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Clinical applications

10

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)
Thiothixene
Pharmacokinetics, Toxicities, Interactions

Oral and parenteral forms, long half-lifes with metabolism-dependent elimination, TOXICITY: extensions of effects on Alpha and M- receptors, blockade of dopamine receptors may result in akathisia, dystonia, parkinsonian symptoms, tardive dyskinesia, and hyperprolactinemia

11

Oral and parenteral forms, long half-lifes with metabolism-dependent elimination, TOXICITY: extensions of effects on Alpha and M- receptors, blockade of dopamine receptors may result in akathisia, dystonia, parkinsonian symptoms, tardive dyskinesia, and hyperprolactinemia

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Pharmacokinetics, Toxicities, Interactions

12

Thiothixene

Thioxanthene

13

Thioxanthene

Thiothixene

14

Thiothixene

Mechanism of action

Blockade of D2 receptors >> 5-HT2A receptors

15

Thiothixene

Effects

a-Receptor blockade
Muscarinic (M)-receptor blockade
H1-receptor blockade
CNS depression (sedation)
Decreased seizure threshold
QT prolongation

16

Thiothixene

Clinical applications

PSYCHIATRIC: schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase) NONPSYCHIATRIC: antiemesis, preoperative sedation (promethazine), pruritus

17

Thiothixene

Pharmacokinetics, Toxicities, Interactions

Oral and parenteral forms, long half-lifes with metabolism-dependent elimination, TOXICITY: extensions of effects on Alpha and M- receptors, blockade of dopamine receptors may result in akathisia, dystonia, parkinsonian symptoms, tardive dyskinesia, and hyperprolactinemia

18

Butyrophenone

Haloperidol

19

Haloperidol

Butyrophenone

20

Haloperidol

Mechanism of action

Blockade of D2 receptors >> 5-HT2A receptors

21

Haloperidol

Effects

Some Alpha blockade, but minimal M-receptor blockade and much less sedation than the phenothiazines

22

Some Alpha blockade, but minimal M-receptor blockade and much less sedation than the phenothiazines

Haloperidol

Effects

23

Haloperidol

Clinical applications

Schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase), Huntington's chorea, Tourette's syndrome

24

Schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase), Huntington's chorea, Tourette's syndrome

Haloperidol

Clinical applications

25

Haloperidol

Pharmacokinetics, Toxicities, Interactions

Oral and parenteral forms with metabolism-dependent elimination, TOXICITY: extrapyramidal dysfunction is a major adverse effect

26

Oral and parenteral forms with metabolism-dependent elimination, TOXICITY: extrapyramidal dysfunction is a major adverse effect

Haloperidol

Pharmacokinetics, Toxicities, Interactions

27

Atypical antipsychotics

Aripiprazole
Clozapine
Olanzapine
Quetiapine
Risperidone
Ziprasidone

28

Aripiprazole

Atypical antipsychotic

29

Clozapine

Atypical antipsychotic

30

Olanzapine

Atypical antipsychotic

31

Quetiapine

Atypical antipsychotic

32

Risperidone

Atypical antipsychotic

33

Risperidone

Atypical antipsychotic

34

Blockade of 5-HT2A receptors > blockade of D2 receptors

Aripiprazole
Clozaine
Risperidone
(atypical antipsychotic)

Mechanism of action

35

Aripiprazole
Clozaine
Risperidone
(atypical antipsychotic)

Mechanism of action

Blockade of 5-HT2A receptors > blockade of D2 receptors

36

Aripiprazole
Clozaine
Risperidone
(atypical antipsychotic)

Clinical applications

Schizophrenia- improve both positive and negative symptoms, bipolar disorder (olanzapine or risperidone adjunctive with lithium), agitation in Alzheimer's and Parkinson's patients (low doses), major depression (aripiprazole)

37

Schizophrenia- improve both positive and negative symptoms, bipolar disorder (olanzapine or risperidone adjunctive with lithium), agitation in Alzheimer's and Parkinson's patients (low doses), major depression (aripiprazole)

Aripiprazole
Clozaine
Risperidone
(atypical antipsychotic)

Clinical applications