August 26, 2015 - Anti-Fungals Flashcards Preview

COURSE 1 > August 26, 2015 - Anti-Fungals > Flashcards

Flashcards in August 26, 2015 - Anti-Fungals Deck (10):
1

Differences Between Human and Fungal Cells

Humans have cholesterol while fungus has ergosterol.

Fungus has chitin and glucan in their cell walls.

2

Types of Fungus

1. Yeast - unicellular and reproduce by budding

2. Mold - filamentous with specialized reproduction apparatus

3. Dimorphic - either a yeast or a mold depending on the temperature of the surroundings. Often will be a yeast in the body at warm temperatures and a mold in the surroundings at cooler temperatures.

3

Common Types of Yeast

1. Candida albicans

2. Candida "non"-albicans

3. Cryptococcus neoformans

4

Common Types of Mold

1. Aspergillus

2. Zygomycosis

3. Dermatophytes (tinia)

5

Common Types of Dimorphic

Many of these are endemic to different regions.

6

Targets for Anti-Fungal Drugs

1. Glucan synthetase inhibitors

2. Cell membrane disruption / pore formation

3. Ergosterol synthesis inhibitors

4. DNA synthesis inhibitors

7

Echinocandins

All end in -FUNGIN

Active against ALL Candida 

Mechanism is to target glucan synthesis

8

Polyenes

Amphotericin B (AmphoTerrible), Liposomal AmphoB, and Nystatin.

All target the cell membrane.

All very toxic in IV form.

 

Liposomal AmphoB is the first line treatment for Zygomycosis however (face melting disease with horrible prognosis).

9

Azoles

All end in -AZOLE

All target ergosterol synthesis

All have high oral bioavailability. PO = IV

10

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