September 30, 2015 - T Cell Physiology Flashcards Preview

COURSE 1 > September 30, 2015 - T Cell Physiology > Flashcards

Flashcards in September 30, 2015 - T Cell Physiology Deck (10):
1

Variable Region

Binds the antigen.

2

T Cell Selection

Occurs in the Thymus.

Very few cells actually "graduate" the thymus. TCRs that can't interact with self MHC molecules are destroyed, and TCRs that are too attracted to self MHC are destroyed.

3

Subsets of CD4 T Cells

TH1 - Intracellular microorganisms

TH2 - Parasitic infections

TH17 - Extracellular bacteria and fungi

Treg - Tolerance

4

TH1 Cells

Important for stimulating macrophages and stimulating antibody production.

Important for the ingestion and killing of INTRAcellular microbes.

5

TH2 Cells

Stimulates the production of IgE antibodies as well as activating eosinophils.

Helpful for fighting helminth parasites.

6

TH17 Cells

Capable of recruiting neutrophils and causing inflammation. Also are implicated for their role in autoimmune diseases.

7

Treg Cells

Immunosuppressive cells.

8

Central Tolerance

Learned in Thymus.

9

Peripheral Tolerance

When mature T cells recognize self-antigens in peripheral tissues (that weren't in the Thymus). Inactivation of the cell occurs normally.

10

Autoimmunity

The loss of immunological tolerance.

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