August 10, 2015 - Gastric Secretion Flashcards Preview

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Flashcards in August 10, 2015 - Gastric Secretion Deck (13):

Mucus Cells

Secrete mucus and pepsinogen II.


Parietal Cells

Secrete HCl and intrinsic factor.


(Intrinsic factor is needed for the absorption of vitamin B12 later in the small intestine)


Chief Cells

Secrete pepsinogen I


D Cells

Secrete somatostatin


(Somatostatin acts directly on the acid-producing parietal cells thus antagonizing the stimulatory effect of histamine to reduce acid secretion.)


G Cells

Secrete gastrin


(Gastrin is a peptide hormone that stimulates the secretion of HCl by the parietal cells of the stomach)


Mast Cells

Secrete histamine


Things that will cause an increase in acid secretion

- Histamine

- Acetylcholine

- Gastrin


Things that will cause a decrease in acid secretion

- Prostaglandins

- Somatostatin


Zollinger-Ellison Syndrome

Is caused by a non-beta islet cell (islet of Langerhands) gastrin-secreting tumor of the pancrease that stimulates the acid-secreting cells of the stomach to maximal activity, with consequent gastrointestinal mucosal ulceration. The high acidity causes multiple ulcers to form in the stomach and duodenum.

The primary tumor is usually located in the pancreas, duodenum, or abdominal lymph nodes.


TREATMENT is done by administering proton pump inhibitors and tumors may need to be surgically removed or treated with chemotherapy.


Peptic Ulcer Disease Symptoms

Abdominal pain that may be described as...

-Burning, gnawing

-Stabbing through the back

-Worsen with food (often gastric ulcers)

-Improve with eating (often duodenal ulcer)

Will also typically include...

-Bloating or cramping

-Nausea, vomiting (blood or coffee-grounds)

-Decreased appetite

-Weight loss

-Bloody or tarry black stolls

-Fatigue and malaise


Agressive Factors for Ulcers

- Acid, pepsin


- Alcohol

- Bile

- H. pylori


Helicobacter pylori and the World

In North America, adults are typically 20-30% positive

In developing countries, adults are 80-90% positive



Acquisition generally occurs in childhood through the drinking of contaminated water, or through oral-oral or oral-fecal routes.


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