October 15, 2015 - Abdominal Pain and Fever Flashcards Preview

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Flashcards in October 15, 2015 - Abdominal Pain and Fever Deck (14):


Yellow deposits near the eyes. Usually indicates high cholesterol if there is no family history of it.


A image thumb

Next Test After Cholestatic Liver Enzymes

Abdominal ultrasound to look at the bile ducts for dilation.

*Note* ducts may not dilate in PSC.


Primary Sclerosing Cholangitis

A disease of the bile ducts that causes inflammation and obliterative fibrosis of the bile ducts inside and/or outside the liver. This impedes the flow of bile to the intestines and can ultimately lead to cirrhosis of the liver, liver failure, and other complications such as bile duct cancer, liver cancer, and colon cancer.

75% of those who have PSC have IBD.


Signs and Symptoms of PSC

Intese pruritis

Severe fatigue


Episodes of acute cholangitis

Dark urine

Steatorrhea (poor fat digestion)



Primary Biliary Cholangitis

An autoimmune disease of the liver. It is marked by the slow progressive destruction of the small bile ducts of the liver, with the intralobular ducts and intrahepatic ductules affected early in the disease. When these ducts are damaged, bile and other toxins build up in the liver and causes liver damage over time. This can lead to scarring, fibrosis, and cirrhosis.

Tested for with AMA


AMA Test

Used to test for PBC


Types of PSC

Large duct (95%) and small duct (5%)


Route for Liver Biopsy

Can go through the side into the liver, or can go through the jugular in the neck.

If the patient has low platelets or a high INR, you must go through the neck. Risks of a liver biopsy are bleeding, infection, and pain.


Ursodeoxycholic Acid (UDCA)

Is effective for PBC

May not be good for PSC, but may be as well...


Makes bile more water soluble so it flows out easier. Makes it harder to absorb fat too, so you need to put them on Vitamin ADEK.


Used to treat PBC. The drug reduces cholesterol absorption and is used to dissolve cholesterol gallstones in patients who want an alternative to surgery.


Septic Shock

A medical condition as a result of severe infection and sepsis. It can cause multiple organ dysfunction and death.

Presents with hypotension, tachypnea, elevated or low WBC count, tachycardia, and altered body temperature.



Is a whole-body inflammatory response to an infection. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion.


Lab Signs of DIC

INR increased

PTT increased

Fibrinogen decreased

Creatinine normal/increased

Liver tests normal

Blood pressure low/normal



Caused by a defect or absence of ADAMTS13.

vWF multimers cannot be cleaved, which results in increased platelet adhesion to endothelial injuries, particularly at ateriole-capullary junctions.


Complications of PSC


Colon cancer

Gall bladder cancer (often removed)


Fat-soluble vitamin deficiencies

Metabolic bone disease

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